Identification of novel drug targets with Omics-based mechanismsfor obesity treatment
Identification of novel drug targets with Omics-based mechanismsfor obesity treatment
批准号:
23659136
负责人:
TANAKA Toshio
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
We found new candidate genes for obesity treatment using DNA microarray experiments and pathway analyses with zebrafish model of diet-induced obesity. Gene knockdown studies of these candidates using morpholino antisense oligonucleotides revealed that several genes including mxd3 could ameliorated the disease phenotypes in model animals. In addition, we clarify the mechanism of these therapeutic effects by Omics research approach.
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DOI:
--
发表时间:
2011
期刊:
Zebrafish December
影响因子:
--
作者:
[Liqing Zang, Daizo Morikane, Yasuhito Shimada, Toshio Tanaka, and Norihiro Nishimura]
通讯作者:
and Norihiro Nishimura
新しい生活習慣病モデルとオミックス医学
新的生活方式疾病模型和组学医学
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tainaka T, Shimada Y, Kuroyanagi J, Zang L, Oka T, Nishimura Y, Nishimura N, Tanaka T., 島田 康人, 島田 康人, 島田 康人, 西村 有平, 西村 有平, 島田 康人, 田中 利男, 田中 利男, 田中 利男]
通讯作者:
田中 利男
蛍光in vivoハイスループット摂食量測定技術による定量的システムズ薬理学研究
利用荧光体内高通量食物摄入测量技术进行定量系统药理学研究
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Tainaka T, Shimada Y, Kuroyanagi J, Zang L, Oka T, Nishimura Y, Nishimura N, Tanaka T., 島田 康人]
通讯作者:
島田 康人
新しいin vivo イメージングとオミックス創薬
新的体内成像和组学药物发现
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tainaka T, Shimada Y, Kuroyanagi J, Zang L, Oka T, Nishimura Y, Nishimura N, Tanaka T., 島田 康人, 島田 康人, 島田 康人, 西村 有平]
通讯作者:
西村 有平
Toshiyuki Tainaka, Yasuhito Shimada,Junya Kuroyanagi, Liqing Zang, Takehiko Oka, Yuhei Nishimura, Norihiro Nishimura and Toshio Tanaka
Toshiyuki Tainaka、Yasuhito Shimada、Junya Kuroyanagi、Liqing Zang、Takehiko Oka、Yuhei Nishimura、Norihiro Nishimura 和 Toshio Tanaka
DOI:
--
发表时间:
2011
期刊:
Nutrition & Metabolism
影响因子:
4.5
作者:
[Liqing Zang, Daizo Morikane, Yasuhito Shimada, Toshio Tanaka, and Norihiro Nishimura, Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model]
通讯作者:
Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model
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Studies on the establishment of sheep production system in less-favored areas
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批准号:25450410
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2013
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负责人:TANAKA Toshio
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依托单位:
Simplification of furnished cages for laying hens in consideration of their health and comfort, and economical points.
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批准号:22580314
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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Development of vacuole-targeting antifungal chemotherapy for suicide induction
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批准号:20580083
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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A study on correlation between standards of metabolic syndrome and musculoskeletal indices
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批准号:20700502
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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财政年份:2008
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负责人:TANAKA Toshio
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依托单位:
Study on the development of exercise applied Awa-Dance to and function and effect of it.
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批准号:20500597
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2008
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负责人:TANAKA Toshio
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Diet treatment by flavonoid for allergic diseases
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批准号:19591165
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:TANAKA Toshio
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Evaluation of condition of health and environment for laying hens : multifactorial comparison of cage and alternative systems
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批准号:19580318
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
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财政年份:2007
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负责人:TANAKA Toshio
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依托单位:
Prediction of onset of allergic diseases through analysis of single nucleotide polymorphisms and prevention of onset of allergic diseases by an appropriate intake of flavonoids
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批准号:17591040
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2005
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负责人:TANAKA Toshio
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依托单位:
Pharmacoproteomic mechanisms in stress protein expression induction
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批准号:14207003
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.62万
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财政年份:2002
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负责人:TANAKA Toshio
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依托单位:
Pharmacogenomics of thyroid disease in molecular target discovery
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批准号:13557221
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.1万
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财政年份:2001
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负责人:TANAKA Toshio
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依托单位:
Analysis of determinants responsible for preferential development of Th2 cells in allergic diseases
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批准号:11670445
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:1999
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负责人:TANAKA Toshio
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依托单位:
The Research about The Application of Cognitive-Behavior Therapy to the Exercise Program Targeted on the Workers with Lifestyle-related Disease
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批准号:10680034
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.9万
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财政年份:1998
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负责人:TANAKA Toshio
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依托单位:
Genome pharmacology on novel calcium signaling in diseases
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批准号:10044267
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资助金额:$5.44万
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财政年份:1998
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负责人:TANAKA Toshio
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依托单位:
Clinical Therapeutic Research of Calcium Sensitization
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批准号:10470511
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.94万
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财政年份:1998
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负责人:TANAKA Toshio
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依托单位:
Studies on the visual acuity and numerical cognition in dogs using an operant conditioning method
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批准号:10660293
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.66万
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财政年份:1998
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负责人:TANAKA Toshio
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依托单位:
Molecular cell pharmacology on calcium signaling in diseases
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批准号:09044285
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$3.2万
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财政年份:1997
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负责人:TANAKA Toshio
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依托单位:
Active induction of allergen specific Th1 cells for atopic asthma
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批准号:09670475
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1997
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负责人:TANAKA Toshio
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依托单位:
Novel Molecular Pharmacological Strategy in Clinical Therapeutic Research
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批准号:08557144
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$10.43万
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财政年份:1996
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负责人:TANAKA Toshio
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依托单位:
Molecular cell pharmacology on Novel calcium signaling
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批准号:08044270
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$2.88万
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财政年份:1996
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负责人:TANAKA Toshio
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依托单位:
Ocular surface cell responce to the injury
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批准号:08672019
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项目类别:Grant-in-Aid for Scientific Research (C)
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负责人:TANAKA Toshio
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依托单位:
海外基金