Physiological functions of novel mammalian glycerophosphodiester phosphodiesterases

点击翻译按钮获取中文摘要

This study isolated a novel GP-PDE, GDE5, and showed that GDE5 selectively hydrolyzes glycerophosphocholine (GroPCho). We show that that decreasing GDE5 abundance promoted myoblastic differentiation. Furthermore, transgenic mice specifically expressing GDE5 in skeletal muscle showed less skeletal muscle mass, especially type II fiber-rich muscle. These results indicate that GDE5 negatively regulates skeletal muscle development, providing novel insight into the biological significance of mammalian GP-PDE functions.