Function and the molecular mechanism of ascorbic acid in zone-specific steroidogenesis of the adrenal cortex
Function and the molecular mechanism of ascorbic acid in zone-specific steroidogenesis of the adrenal cortex
批准号:
20580142
负责人:
MITANI Fumiko
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The level of near to 20mM ascorbic acid (Asc) in the adrenal gland is the highest in a body. The purpose of this study was to investigate the possible participation of Asc in the zone-specific steroidogenesis. By employing rat mutants unable to synthesize Asc, Asc was shown to be a reducing factor supporting the classical reducing system specifically in aldosterone synthesis in the zona glomerulosa (zG). One of the components in the regeneration system of Asc, OMb, was abundant in zG, which seems to support above results.
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DOI:
10.1210/jc.2009-2010
发表时间:
2010-05-01
期刊:
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
影响因子:
5.8
作者:
[Nishimoto, Koshiro, Nakagawa, Ken, Mukai, Kuniaki]
通讯作者:
Mukai, Kuniaki
Cytochrome P450 (17alpha)in beta-cells of rat pancreas and its local steroidogenesis
大鼠胰腺β细胞中的细胞色素P450 (17α)及其局部类固醇生成
DOI:
--
发表时间:
2008
期刊:
J Steroid Biochem Mol Biol 111
影响因子:
--
作者:
[Ogishima T, Mitani F, Suematsu M.]
通讯作者:
Suematsu M.
イラストレイテッドハーパー・生化学(原書28版)
哈珀生物化学图解(原版第 28 版)
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tochigi Y, Sato N, Sahara T, Wu C, Saito S, Irie T. Fujibuchi W, Goda T, Yamaji R, Ogawa M, Ohmiya Y, Ohgiya S., 丸善株式会社]
通讯作者:
丸善株式会社
ヒト副腎皮質における自律的アルドステロン産生細胞クラスター
人肾上腺皮质自主产生醛固酮的细胞群
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[西本紘嗣郎、三谷芙美子、向井邦晃, 他]
通讯作者:
他
Localization of cytochrome P450 and production of local steroids in pancreatic β-cells
细胞色素 P450 的定位和胰腺 β 细胞中局部类固醇的产生
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yoshino K, Ogishima T, Mitani F, et al.]
通讯作者:
et al.
共 15 条
Analysis on the lineage of adrenocortical cells with 3-dimentional arrangement
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批准号:15570052
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:2003
-
负责人:MITANI Fumiko
-
依托单位:
Adrenocortical tissue formed by transplantation of undifferentiated cells
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批准号:13640668
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2001
-
负责人:MITANI Fumiko
-
依托单位:
Identification of genes regulating the differentiation of adrenocotical stem cells and their functional mechanisms
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批准号:10680675
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:1998
-
负责人:MITANI Fumiko
-
依托单位:
Properties of Aldosterone Synthase and the Regulation Mechanism in Adrenocortex.
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批准号:62580155
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1987
-
负责人:MITANI Fumiko
-
依托单位:
海外基金