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Function and the molecular mechanism of ascorbic acid in zone-specific steroidogenesis of the adrenal cortex

Function and the molecular mechanism of ascorbic acid in zone-specific steroidogenesis of the adrenal cortex
抗坏血酸在肾上腺皮质区域特异性类固醇生成中的功能和分子机制
批准号:
20580142
负责人:
MITANI Fumiko
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
The level of near to 20mM ascorbic acid (Asc) in the adrenal gland is the highest in a body. The purpose of this study was to investigate the possible participation of Asc in the zone-specific steroidogenesis. By employing rat mutants unable to synthesize Asc, Asc was shown to be a reducing factor supporting the classical reducing system specifically in aldosterone synthesis in the zona glomerulosa (zG). One of the components in the regeneration system of Asc, OMb, was abundant in zG, which seems to support above results.
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DOI: 10.1210/jc.2009-2010
发表时间: 2010-05-01
期刊: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
影响因子: 5.8
作者: [Nishimoto, Koshiro, Nakagawa, Ken, Mukai, Kuniaki]
通讯作者: Mukai, Kuniaki
Cytochrome P450 (17alpha)in beta-cells of rat pancreas and its local steroidogenesis
大鼠胰腺β细胞中的细胞色素P450 (17α)及其局部类固醇生成
DOI: --
发表时间: 2008
期刊: J Steroid Biochem Mol Biol 111
影响因子: --
作者: [Ogishima T, Mitani F, Suematsu M.]
通讯作者: Suematsu M.
イラストレイテッドハーパー・生化学(原書28版)
哈珀生物化学图解(原版第 28 版)
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Tochigi Y, Sato N, Sahara T, Wu C, Saito S, Irie T. Fujibuchi W, Goda T, Yamaji R, Ogawa M, Ohmiya Y, Ohgiya S., 丸善株式会社]
通讯作者: 丸善株式会社
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [西本紘嗣郎、三谷芙美子、向井邦晃, 他]
通讯作者:
15
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    • 批准号:
      15570052
    • 项目类别:
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    • 资助金额:
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    • 财政年份:
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