Possibility of prevention with crude drugs or Kampo medicine on chemical carcinogenesis

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In our ongoing studies of anti-tumor promoters from natural products, we have examined a number of chinese medicinal plants, kampo-prescriptions and natural alternative sweeteners. In these experiments, the conventional primary screening test on the inhibitory effects of Epstein-Barr virus early antigen (EBV-EA) induction using Raji cells as an indicator cell and TPA as a promoter have been carried out. More than four hundred crude extracts of Chinese herbal medicines were tested, and seven extracts exhibited the significant inhibitory effects on EBV-EA activation. Of these samples, Eriocaulon buergerianum(gu jing cao), Nelumbo nucifera(lian fang)and stevioside exhibited the remarkable chemopreventive effects on mouse skin two-stage carcinogenesis test. These results strongly suggested the possibility of the crude drugs and kampo medicines on the prevention of chemical carcinogenesis.