Studies on the Bioactivity and Intensive Use of the Constituents of Azadirachta indica (Neem)
Studies on the Bioactivity and Intensive Use of the Constituents of Azadirachta indica (Neem)
批准号:
20590015
负责人:
AKIHISA Toshihiro
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Thirty-one limonoids and one diterpenoid, and seventeen limonoids were isolated from the methanol and hexane extracts, respectively, of neem seeds. Among these compounds, seven were new compounds, and their structures were determined spectroscopically. These compounds were evaluated for their melanogenesis-inhibitory, anti-inflammatory, Epstein-Barr virus early antigen (EBV-EA) activation inhibitory, and cytotoxic activities. Some of these compounds have been revealed to possess potent melanogenesis-inhibitory, anti-inflammatory, EBV-EA activation inhibitory, and cytotoxic activities with apoptosis induction.
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ニーム葉部リモノイド成分の細胞傷害および抗炎症活性, ならぴにEBV活性化抑制効果
印楝叶中柠檬苦素类成分的细胞毒和抗炎活性、EBV激活对Naramini的抑制作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Iijima Y., Fujiwara Y., Tokita T., Ikeda T., Nohara T., Aoki K., Shibata D., Naoki Kakusawa, 高木 美緒]
通讯作者:
高木 美緒
Cytotoxic and apoptosis -inducing activities of limonoids from the seed extract of Azadirachta indica A.Juss. (neem)
印楝种子提取物中柠檬苦素的细胞毒性和细胞凋亡诱导活性。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takashi Kikuchi, Koichi Ishii, Taisuke Noto, Akitomo Takahashi, Keiichi Tabata, Takashi Suzuki, Toshihiro Akihisa]
通讯作者:
Toshihiro Akihisa
ニーム種子由来成分のメラニン産生抑制活性
印楝种子成分的黑色素生成抑制活性
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Li D.-P., El-Aasr M., Ikeda T., Ogata M., Miyashita H., Yoshimitsu H., Nohara T., Hidemasa Hikawa, Masatoshi Kawabata, 高橋章友,秋久俊博,能登泰輔,伴野規博,藤田幸子,鈴木孝,木村由美子]
通讯作者:
高橋章友,秋久俊博,能登泰輔,伴野規博,藤田幸子,鈴木孝,木村由美子
DOI:
10.5650/jos.60.53
发表时间:
2011-02-01
期刊:
JOURNAL OF OLEO SCIENCE
影响因子:
1.5
作者:
[Akihisa, Toshihiro, Takahashi, Akitomo, Yasukawa, Ken]
通讯作者:
Yasukawa, Ken
Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indica A.Juss. (neem)
印楝种子中柠檬苦素的黑色素生成抑制、抗炎和化学预防作用。
DOI:
--
发表时间:
2009
期刊:
Journal of Oleo Science 58巻
影响因子:
--
作者:
[Toshihiro Akihisa, Taisuke Noto, Akitomo Tkahashi, Yukiko Fujita, Norihiro Banno, Harukuni Tokuda, Kazuo Koike, Takashi Suzuki, Ken Yasukawa, Yumimko Kimura]
通讯作者:
Yumimko Kimura
共 17 条
Development of New Chemopreventive Agents from Monascus pilosus-Fermented Rice (Red-Mold Rice)
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批准号:14572101
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
-
财政年份:2002
-
负责人:AKIHISA Toshihiro
-
依托单位:
海外基金