Sp3 and its regulatory effect of gene expression provide new insights to treat chronic obstructive pulmonary disease.

在这项研究中，我们研究了SP3在肺泡细胞分化过程中的作用。我们发现SP3在肺泡II型细胞和间充质细胞中表达，而在I型细胞中不表达，并且SP3的过表达显著增加了一种酶的mRNA表达，该酶是合成肺表面活性物质的重要因素。此外，SP3可能参与了IL-6和STAT3依赖的基因表达。此外，通过激活ERK和CEBP，肿瘤坏死因子-α可降低SP3和水通道蛋白-3的表达。

In this study, we examined the role of Sp3 in alveolar cells, during differentiation. We have found that Sp3 is expressed in alveolar type II cells and mesenchymal cells, but not in type I cells, and that overexpression of Sp3 considerably increased mRNA expression of an enzyme, which is important to synthesis pulmonary surfactant. In addition, Sp3 may be involved in IL-6- and STAT3-dependent gene expression. Further, expression of Sp3 and aquaporin-3 was decreased by TNF-alpha, through the activation of ERK and CEBP.