Research of drug-resistant mechanism in highly pathogenic avian influenza virus

H5 N1禽流感病毒在许多亚洲国家的持续存在及其在人类中造成致命感染的能力引起了人们对全球流感大流行的严重关切。主要结果如下：（1）从奥司他韦治疗的患者中分离到对奥司他韦耐药的H5 N1病毒。研究药物T-705有效地保护小鼠免受这些病毒的致命感染。(2)在印度尼西亚，H5 N1病毒曾多次传播给猪。(3)对患者体内H5 N1病毒RNA的直接分析显示，病毒在人体内的有效繁殖。培养物或鸡蛋中生长的病毒并不总是反映患者体内的病毒。(4)许多流感快速诊断测试可用于检测H5 N1流感病毒感染。

The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. We obtained important results as below :(1) Oseltamivir-resistant H5N1 viruses have been isolated from oseltamivir-treated patients. The investigational drug T-705 has effectively protects mice from lethal infection with these viruses.(2) H5N1 viruses have been transmitted to pigs on multiple occasions in Indonesia.(3) A direct analysis of the viral RNAs of H5N1 viruses in patients revealed that efficient virus propagation in the human. Viruses grown in culture or eggs did not always reflect those in patients.(4) Many influenza rapid diagnostic tests are available for the detection of H5N1 influenza virus infections.