Influenza A (H5N1) viruses from pigs, Indonesia.
Influenza A (H5N1) viruses from pigs, Indonesia.
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DOI：
10.3201/eid1610.100508
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发表时间：
2010-10
影响因子：
11.8
通讯作者：
Kawaoka Y
中科院分区：
文献类型：
--
作者：
Nidom CA;Takano R;Yamada S;Sakai-Tagawa Y;Daulay S;Aswadi D;Suzuki T;Suzuki Y;Shinya K;Iwatsuki-Horimoto K;Muramoto Y;Kawaoka Y
TOC摘要：猪可能是这种禽流感病毒适应哺乳动物的中间宿主。长期以来，猪一直被认为是禽流感病毒适应人类的潜在中间宿主。为了确定印度尼西亚的猪是否存在这种可能性，我们在2005-2009年间进行了监测。我们发现4个省的52头猪在2005-2007年感染了猪，而2008-2009年没有感染。系统发育分析表明，这些病毒至少3次被引入印度尼西亚的猪群。其中一个分离株已经获得了识别人类类型受体的能力。没有受感染的猪出现类似流感的症状，这表明甲型H5N1流感病毒可以在很长一段时间内在未被检测到的情况下复制，从而促进禽流感病毒适应哺乳动物宿主。我们的数据表明，在甲型H5N1流感病毒暴发期间，猪有感染的风险，可以作为这种禽流感病毒适应哺乳动物的中间宿主。
TOC summary: Pigs may serve as intermediate hosts in which this avian virus can adapt to mammals. Pigs have long been considered potential intermediate hosts in which avian influenza viruses can adapt to humans. To determine whether this potential exists for pigs in Indonesia, we conducted surveillance during 2005–2009. We found that 52 pigs in 4 provinces were infected during 2005–2007 but not 2008–2009. Phylogenetic analysis showed that the viruses had been introduced into the pig population in Indonesia on at least 3 occasions. One isolate had acquired the ability to recognize a human-type receptor. No infected pig had influenza-like symptoms, indicating that influenza A (H5N1) viruses can replicate undetected for prolonged periods, facilitating avian virus adaptation to mammalian hosts. Our data suggest that pigs are at risk for infection during outbreaks of influenza virus A (H5N1) and can serve as intermediate hosts in which this avian virus can adapt to mammals.
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影响因子：
9.4
作者：
Hatakeyama, S;Sakai-Tagawa, Y;Kawaoka, Y
通讯作者：
Kawaoka, Y
影响因子：
168.9
作者：
Claas, ECJ;Osterhaus, ADME;Webster, RG
通讯作者：
Webster, RG
影响因子：
3.7
作者：
Takano, Ryo;Nidom, Chairul A.;Kawaoka, Yoshihiro
通讯作者：
Kawaoka, Yoshihiro
影响因子：
3.7
作者：
Gambaryan, A;Tuzikov, A;Klimov, A
通讯作者：
Klimov, A
影响因子：
56.9
作者：
Subbarao, K;Klimov, A;Cox, N
通讯作者：
Cox, N