Effects of chemical compounds derived from plants on the functions of catecholaminergic neurons and life span

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We examined the effects of chemical compounds derived from plants on catecholamine dynamics in cultured bovine adrenal medullary cells used as a model of sympathetic neurons. We found that nobiletin (a flavonoids of citrus fruits), nicotine (one of major components of cigarette smoke), and genistein (one of the major soy phytoestrogens) had various effects on catecholamine synthesis, secretion, and reuptake in cultured bovine adrenal medullary cells. Because of nutritionally relevant concentrations used in the present study, we must pay an attention to the pharmacological effects of these plant chemical compounds.