Search for agonists of new plasma membrane estrogen receptors and their anti-stress effects

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The agonists of plasma membrane estrogen receptors were investigated. Daidzein and genistein, soy isoflavones, and resveratrol, a grape polyphenol, inhibited the specific binding of [3H]17beta-estradiol to plasma membranes isolated from bovine adrenal medulla. These phytoestrogens and a plant flavonoid, nobiletin, inhibited catecholamine synthesis and secretion induced by acetylcholine in cultured bovine adrenal medullary cells. Resveratrol also affected the function of noradrenaline transporter in SK-N-SH cells (human neuroblastoma cell line). These results suggest that phytoestrogens and some plant flavonoids have protective effects against stresses.