Identification and Functional Analysis of the Na^+-Dependent Glycerol Transporter in HCT-15 Cells

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Identification of the Na^+-dependent glycerol transporter, which was attempted by the expression cloning method and the bioinformatic approach using gene databases, was unsuccessful. But it was found that, interestingly, aquaglyceroporins can transport glycerol by a carrier-mediated type of mechanism. Although any of them is unlikely to be the molecular entity of the Na^+-dependent glycerol transporter, the finding would help identifying transporters involved in glycerol disposition and understanding their roles.