Development of brain specific drug delivery system with microglia

小胶质细胞脑特异性药物输送系统的开发

• 批准号: 20590153
• 负责人: MAEDA Tomoji
• 金额: $ 3万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590153/
• 关键词: ミクログリア; ドラッグデリバリーシステム; トランスポーター; DDS; 血液脳関門; 接着因子; 血液脳関; ATP; 走化性因子; 脳毛細血管内皮細胞

In this study, we investigated the possibility whether microglia can be used for brain-targeting drug delivery system, since it was reported that microglia is able to enter the brain from blood flow. At first, we studied the effect of nucleotides on the migration of microglia in our assay system. We found that adenosine triphosphate (ATP), thymidine triphosphate (TTP) and cytidine triphosphate (CTP) induced the migration of microglia.

在这项研究中，我们探讨了小胶质细胞是否可以用于脑靶向药物递送系统，因为有报道称小胶质细胞可以从血流进入大脑。首先，我们在实验系统中研究了核苷酸对小胶质细胞迁移的影响。我们发现三磷酸腺苷（ATP）、三磷酸胸腺嘧啶（TTP）和三磷酸胞苷（CTP）诱导小胶质细胞迁移。

项目成果

Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer

• DOI: 10.1016/j.jsbmb.2010.06.014
• 发表时间: 2010-10-01
• 期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
• 影响因子: 4.1
• 作者: Maeda, Tomoji;Irokawa, Masanori;Tamai, Ikumi
• 通讯作者: Tamai, Ikumi