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Development of brain specific drug delivery system with microglia

Development of brain specific drug delivery system with microglia
小胶质细胞脑特异性药物输送系统的开发
批准号：
20590153
负责人：
MAEDA Tomoji
金额：
$3.0万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590153/
关键词：
ミクログリアドラッグデリバリーシステムトランスポーターDDS血液脳関門接着因子血液脳関ATP走化性因子脳毛細血管内皮細胞

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中文摘要
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英文摘要
In this study, we investigated the possibility whether microglia can be used for brain-targeting drug delivery system, since it was reported that microglia is able to enter the brain from blood flow. At first, we studied the effect of nucleotides on the migration of microglia in our assay system. We found that adenosine triphosphate (ATP), thymidine triphosphate (TTP) and cytidine triphosphate (CTP) induced the migration of microglia.
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Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer
DOI： 10.1016/j.jsbmb.2010.06.014
发表时间： 2010-10-01
期刊： JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
影响因子： 4.1
作者： [Maeda, Tomoji, Irokawa, Masanori, Tamai, Ikumi]
通讯作者： Tamai, Ikumi
Function analysis of endoplasmic reticulum stress inducible protein Herp focused on a calcium release in endoplasmic reticulum
The development of new diagnostic and therapeutic tools for AD based on regulation of the gamma-secretase complex assembly.
  • 批准号：
    23590110
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $3.24万
  • 财政年份：
    2011
  • 负责人：
    MAEDA Tomoji
  • 依托单位：
    Iwate Medical University
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