Analysis of B-FABP as an immunoregulatory factor by modulating omega-3 polyunsaturated fatty acid metabolism

本研究旨在研究omega-3脂肪酸的强结合蛋白--脑型脂肪酸结合蛋白(B-FABP/FABP7)在小鼠外周免疫器官和免疫细胞中的详细分布和功能。B-FABP定位于成纤维细胞网状细胞，构成外周淋巴结和脾T细胞区的基质网状细胞。与野生型小鼠相比，B-FABP基因敲除(KO)小鼠脏器中的CD_4~+细胞比例显著增加，肝脏中B-FABP仅定位于Kupffer细胞。在KO小鼠体内，它们的吞噬活性和在损伤部位的蓄积均显著降低。

The present study was undertaken to examine the detailed distribution and the function of brain-type fatty acid binding protein (B-FABP/FABP7), a strong binder of omega-3 fatty acids, in mouse peripheral immune organs and immune cells.B-FABP was localized to the fibroblastic reticular cells, which construct the stromal reticula in the T cell areas of the peripheral lymph nodes and spleen. In B-FABP knockout (KO) mice, the percentage of CD4^+ cells in the organs was significantly increased compared with that in wild-type mice.In the liver, B-FABP was exclusively localized in Kupffer cells. Their phagocytic activity and accumulation to injured portion were significantly decreased in KO mice.