Anxiety is involved in tonic GABAergic inhibition in cerebral cortex and limbic system

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PRIP1, a novel IP3 binding protein, functioned as a transporter protein of GABAA receptor to plasma membrane. Then PRIP1-KO mice should be changed the GABAergic inhibitory system. KO mice showed decreasing motor activity by an open-field test. Using brain slices and whole-cell patch-clamp recordings, there are no significant difference both amplitude and frequency of mEPSCs and mIPSCS between WT and KO mice. Tonic GABAergic inhibition exist in principal neurons of the basolateral amygdala in WT mice but PRIP-1 KO mice have imperfection of this inhibitory system.