Molecular basis of the rhythmical expression of the genes in the gastrointestinal tract
Molecular basis of the rhythmical expression of the genes in the gastrointestinal tract
批准号:
20590233
负责人:
GODA Toshinao
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
限制摄食时间导致时钟基因(PER 2)和己糖转运蛋白基因(SGLT1)的表达高峰移至开始摄食前。BMAL1和乙酰化组蛋白H3和H4与这些基因的转录区域的结合与它们的表达变化有关。这些结果表明,己糖转运蛋白基因表达的日变化是由时钟基因的反馈环路调节的。
英文摘要
Restricted feeding schedule led to a shift of the peak of the expression of clock gene (per 2) and a hexose transporter gene (sglt1) to just prior to the start of feeding. The binding of BMAL1 and acetylated histone H3 and H4 to the transcribed regions of these genes was associated with changes in their expressions. These results suggest that diurnal changes in expression of hexose transporter genes are regulated by a feedback loop of clock genes.
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Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter GLUT5 during development of rat small intestine.
大鼠小肠发育过程中饮食诱导的肠道果糖转运蛋白 GLUT5 体内表观遗传调控。
DOI:
--
发表时间:
2011
期刊:
Biochem.J.
影响因子:
--
作者:
[Suzuki, T., ら]
通讯作者:
ら
小腸細胞分化・成熟関連転写因子の安定的発現に伴う細胞周期への影響
对与小肠细胞分化和成熟相关的转录因子的稳定表达相关的细胞周期的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[鈴木拓史, 他]
通讯作者:
他
DOI:
10.1016/j.bbagen.2009.08.004
发表时间:
2009-12-01
期刊:
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
影响因子:
3
作者:
[Suzuki, Takuji, Mochizuki, Kazuki, Goda, Toshinao]
通讯作者:
Goda, Toshinao
小腸様細胞株Caco-2の分化に伴うGLUT5遺伝子発現増大におけるヒストンH3K4のメチル化の役割
组蛋白 H3K4 甲基化在小肠样细胞系 Caco-2 分化过程中增加 GLUT5 基因表达的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[稲用裕子, 他]
通讯作者:
他
時計遺伝子による小腸消化吸収関連遺伝子の発現調節
时钟基因调控小肠消化吸收相关基因的表达
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Orikasa C., Kondo, Y., Usui, S., Sakuma Y., 合田敏尚]
通讯作者:
合田敏尚
共 31 条
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Regulation of the expression of microvillar lactase in small intestine
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海外基金