Study on risk reduction of lifestyle-related diseases due to modulations of digestion/absorption capability of carbohydrates.

通过调节碳水化合物的消化/吸收能力来降低与生活方式相关的疾病风险的研究。

• 批准号: 23300276
• 负责人: GODA Toshinao
• 金额: $ 11.73万
• 依托单位: University of Shizuoka
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23300276/
• 关键词: 食後高血糖; 小腸; バイオマーカー; 遺伝子発現; 慢性炎症

The hypothesis that suppression of postprandial hyperglycemia due to retardation of digestion/absorption of carbohydrates leads to reductions of chronic inflammation and resulting lifestyle-related disease risk, was examined in animal models and human subjects.Feeding a diet containing resistant starch (RS) or alpha-glucosidase inhibitor (miglitol) in type 2 diabetes model rats caused a reduction in postprandial glycemic levels, and it led to suppression of inflammation-related gene expressions in adipose tissue and peripheral leukocytes, along with reduced expression of cell adhesion molecules in aorta tissue. The postprandial hyperglycemia-associated inflammation was suppressed by consumption of anti-oxidation food factors such as EGCG. Cross-sectional studies of healthy subjects showed that a higher rate of eating is associated with plasma IL-1b levels, suggesting that IL-1b is a marker for inflammation, presumably caused by hyperglycemia.

在动物模型和人类受试者中检验了由于碳水化合物的消化/吸收延迟而抑制餐后高血糖导致慢性炎症和由此产生的生活方式相关疾病风险降低的假设。（米格列醇）在2型糖尿病模型大鼠中引起餐后血糖水平降低，并导致脂肪组织和外周白细胞中炎症相关基因表达的抑制，沿着主动脉组织中细胞粘附分子表达的降低。餐后高血糖相关炎症可通过食用抗氧化食物因子（如表没食子酸酯）来抑制。对健康受试者的横断面研究表明，较高的进食率与血浆IL-1b水平相关，这表明IL-1b是炎症的标志物，可能由高血糖引起。

项目成果

A higher rate of eating is associated with higher circulating interleukin-1b concentrations in Japanese men not being treated for metabolic diseases.

在未接受代谢性疾病治疗的日本男性中，较高的进食率与较高的循环白细胞介素 1b 浓度相关。

• 发表时间: 2012
• 期刊: Nutrition
• 影响因子: 4.4
• 作者: Mochizuki;K.ら
• 通讯作者: K.ら

Cotreatment of miglitol and sitagliptin reduces circulating proteins related to CVD in type 2 diabetic Japanese patients.

米格列醇和西他列汀的联合治疗可减少日本 2 型糖尿病患者中与 CVD 相关的循环蛋白。

• 作者: Setsuko NAKAYAMA;Yoko ITO;合田敏尚;今井千裕ら;山崎順平ら;麻植有希子ら;合田敏尚;合田敏尚;針谷夏代ら;今井千裕ら
• 通讯作者: 今井千裕ら

Trimethylation of histone H3K4 is associated with the induction of fructose-inducible genes in rat jejunum.

• DOI: 10.1016/j.bbrc.2012.02.043
• 发表时间: 2012-03
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Y. Yoshinaga;K. Mochizuki;T. Goda

Associations between Leukocyte Counts and Cardiovascular Disease Risk Factors in Apparently Healthy Japanese Men

• DOI: 10.3177/jnsv.58.181
• 发表时间: 2012-06-01
• 期刊: JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
• 影响因子: 1.6
• 作者: Mochizuki, Kazuki;Miyauchi, Rie;Goda, Toshinao
• 通讯作者: Goda, Toshinao

健康中年者において血清γ-GTP活性は、空腹時血糖および血漿IL-1βと正の関連がある：住民健康診査における横断研究

健康中年人血清γ-GTP活性与空腹血糖和血浆IL-1β呈正相关：人群健康体检横断面研究

• 作者: Setsuko NAKAYAMA;Yoko ITO;合田敏尚;今井千裕ら;山崎順平ら
• 通讯作者: 山崎順平ら