Effects of ambient temperatures on rat neonatal hypoxic-ischemic encephalopathy assessed using simple behavioral tests.

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Human neonatal hypoxic-ischemic encephalopathy is one of the most important problems to be solved. Concerning this topic, we produced rat models of hypoxic-ischemic encephalopathy at various ambient temperatures on insult, and assessed motor and learning ability after reaching maturity using simple behavioral tests. The hypoxic-ischemic encephalopathy model rats produced at high ambient temperatures showed retardation of motor and learning abilities compared to those produced at normal ambient temperatures and controls. However, there was no anatomical difference in the brain morphology. These results suggest a discrepancy between the brain anatomy and behavior of rat models of hypoxic-ischemic encephalopathy at various ambient temperatures on insult.