The molecular mechanisms of the convergence in the early stage of the cell growth and adhesion signalings enhanced by glycosphingolipids

点击翻译按钮获取中文摘要

Glycosphingolipid, GD3 is widely expressed in human malignant melanoma cells and tumors. In this study, we analyzed the molecular mechanisms for the convergence in the initial stage of the cell growth and adhesion signalings enhanced by GD3. Our results suggested that the signaling molecules were phosphorylated through the growth factor receptors more strongly in GD3-expressing cells than in GD3 negative cells. This was also the case for signaling via cell adhesion probably due to the assembly and clustering of integrins in lipid rafts, leading to the malignant properties of melanomas under GD3 expression.