Establish of anti-liver metastasis therapy of colorectal cancer-targeting of angiotensin activation system

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Angiotensin provides pro-tumoral effects. Our study reveals colorectal cancer cells possess the hyperglycemia-induced angiotensin-activating mechanism, which is associated with liver metastasis. These findings suggest a new molecular target for liver metastasis of colorectal cancer. MAS1 is a receptor of angiotensin 1-7, which is a degradation product of angiotensin I and II. MAS1 expression is decreased in breast ductal carcinomas, especially in scirrhous carcinomas. MAS1 levels are reversely correlated with stage, nodal metastasis, and HER2 expression. These findings suggest that MAS1 might be a novel tumor suppressor gene in breast cancer.