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Global analysis for epigenetic alterations of hepatic stellate cells in the transformation using Gia-sequencing method.

Global analysis for epigenetic alterations of hepatic stellate cells in the transformation using Gia-sequencing method.
使用 Gia 测序方法对转化过程中肝星状细胞的表观遗传改变进行全局分析。
批准号:
20590370
负责人:
MASUDA Tomoyuki
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
We intensively examined on hepatic stellate cells (HSC) for the treatment strategy of liver fibrosis. The present study focused on epigenetic alterations within the process of HSCs transformation. Using Gia-base sequencing method, global alterations of DNA methylation were examined in HSC under the condition of HDAC inhibitor (TSA) and interferon (IFN)-γ. Of them, genes relating pluripotency of stem cells were altered, and the nucleus accumbens associated-1 (NACC1) might be an important factor along with cMYC and NANOG. These transition of HSC might be induced though epigenetic alterations.
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Detection of human papillomavirus in a urothelial carcinoma mimicking urethral caruncle.
在模拟尿道肉阜的尿路上皮癌中检测人乳头瘤病毒。
DOI: --
发表时间: 2010
期刊: Int J Urol 17
影响因子: --
作者: [Y. Tatemichi, H. Oikawa, C. Maesawa, J. Ambo, M. Sato, H. Koike, T. Sata, T. Fujioka, T. Masuda]
通讯作者: T. Masuda
Accumbens-Associated 1 Contributes to Cortactin Deacetylation and Augments the Migration of Melanoma Cells.
Accumbens-Associated 1 有助于 Cortactin 脱乙酰化并增强黑色素瘤细胞的迁移。
DOI: --
发表时间: 2011
期刊: J Invest Dermatol in press
影响因子: --
作者: [K. Tsunoda, H. Oikawa, H. Tada, Y. Tatemichi, S. Muraoka, S. Miura, M. Shibazaki, F. Maeda, K. Takahashi, T. Akasaka, T. Masuda, C. Maesawa, Nucleus]
通讯作者: Nucleus
Epigenetic modification is involved in aberrant expression of class III beta-tubulin, TUBB3, in ovarian cancer cells.
表观遗传修饰与卵巢癌细胞中 III 类 β-微管蛋白 TUBB3 的异常表达有关。
DOI: --
发表时间: 2008
期刊: Int J Oncol 32
影响因子: --
作者: [Izutsu N, Maesawa C, Masuda T., et al]
通讯作者: et al
Association of the TNF-{alpha}-C-857T polymorphism with resistance to the cholesterol-lowering effect of HMG-CoA reductase inhibitors in type 2 diabetic subjects.
TNF-{α}-C-857T 多态性与 2 型糖尿病受试者对 HMG-CoA 还原酶抑制剂降胆固醇作用的抵抗力的关联。
DOI: --
发表时间: 2010
期刊: Diabetes Care 33
影响因子: --
作者: [T. Takahashi, K. Takahashi, M. Yamashina, C. Maesawa, T. Kajiwara, H. Taneichi, N. Takebe, Y. Kaneko, T. Masuda, J. Satoh]
通讯作者: J. Satoh
22
    Analysis of Mutual Influence Relationships Based on a Comparison of Byzantine and Medieval Italian Church Decoration Programs
    • 批准号:
      18H00632
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $7.49万
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      2018
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      23590431
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    • 资助金额:
      $3.08万
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    • 批准号:
      22320030
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
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    A Historical Study on the Publication of Copybooks in the Qing Dynasty of China
    • 批准号:
      22720266
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.58万
    • 财政年份:
      2010
    • 负责人:
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    • 依托单位:
    海外基金