Analyses of novel genes expressed in the embryonic spinal cord with reference to the sensory axonal guidance

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During early development, the dorsal spinal cord-derived cue chemoattracts dorsal root ganglion(DRG) axons toward the dorsal root entry zone. To identify the molecular nature of this chemoattraction, we examined the function of novel genes expressed in the embryonic dorsal spinal cord. We revealed that a protein encoded by mouse Fukushima 1(mF1) exerted an attractive activity for DRG axons. These results suggest that mF1 may be a candidate for the dorsal spinal cord-derived attractant.