Role of drs tumor suppressor gene on host defense mechanism against infection

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To clarify the physiological function of drs tumor suppressor in non-malignant cells, the role on host defense against infection was investigated. The replication of the viruses including VSV in drs deficient cells, derived from drs knockout mice, was increased compared with that in wild-type cells. drs was associated with stress-inducible GADD34 and TSC2, and regulated mTOR signaling pathway to suppress the viral protein synthesis in the infected cells. It was suggested that drs is involved in the host defense mechanism against viral infection.