Role of drs tumor suppressor gene on host defense mechanism against infection

drs抑癌基因在宿主感染防御机制中的作用

• 批准号: 20590383
• 负责人: TAMBE Yukihiro
• 金额: $ 3万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590383/
• 关键词: drs遺伝子; 感染防御; 自然免疫; mTOR; GADD34; 感染防御作用

To clarify the physiological function of drs tumor suppressor in non-malignant cells, the role on host defense against infection was investigated. The replication of the viruses including VSV in drs deficient cells, derived from drs knockout mice, was increased compared with that in wild-type cells. drs was associated with stress-inducible GADD34 and TSC2, and regulated mTOR signaling pathway to suppress the viral protein synthesis in the infected cells. It was suggested that drs is involved in the host defense mechanism against viral infection.

为了阐明drs肿瘤抑制因子在非恶性细胞中的生理功能，研究了其在宿主抗感染防御中的作用。在drs基因敲除小鼠的drs缺陷细胞中，VSV等病毒的复制比野生型细胞中的病毒复制增加。drs与应激诱导的GADD34和TSC 2相关，通过调节mTOR信号通路抑制病毒蛋白的合成。这表明drs参与了宿主抵抗病毒感染的防御机制。

项目成果

Cyclin Dlb variant prpmotes cell invasiveness independent of binding to CDK in human bladder cancer cells.

细胞周期蛋白 Dlb 变体在人膀胱癌细胞中促进细胞侵袭，与 CDK 的结合无关。

• 发表时间: 2009
• 期刊: Molecular Carcinogenesis (In press)
• 作者: Kim;C. J.;Nishi;K.;Isono;T.;Okuyama;Y.;Tambe;Y.;Okada;Y.;Inoue;H.
• 通讯作者: H.

Role of alternative splicing of periostin in human bladder carcinogenesis.

• DOI: 10.3892/ijo.32.1.161
• 发表时间: 2008
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: C. Kim;T. Isono;Y. Tambe;T. Chano;H. Okabe;Y. Okada;H. Inoue

Cell-type dependent regulation of EMT and cell invasiveness of human cancer cells by periostin

骨膜素对人类癌细胞 EMT 和细胞侵袭性的细胞类型依赖性调节

• 发表时间: 2010
• 作者: Hirokazu Inoue;Kanami Sakamoto;Yukihiro Tambe;Chul Jang Kim
• 通讯作者: Chul Jang Kim

癌抑制遺伝子drsによるウイルス増殖抑制作用

抑癌基因drs抑制病毒增殖

• 发表时间: 2010
• 作者: 旦部幸博;奥山直美;中川達也;井上寛一
• 通讯作者: 井上寛一

Role of drs tumor suppressor gene in cell survival under energy depletion

drs抑癌基因在能量消耗下细胞存活中的作用

• 发表时间: 2009
• 作者: Hirokazu Inoue;Tokuhiro Chano;Yukihiro Tambe
• 通讯作者: Yukihiro Tambe