Regulation of metabolic shift by drs tumor suppressor gene

点击翻译按钮获取中文摘要

The drs gene is the tumor suppressor gene that regulates apoptosis and autophagy in cancer cells. However, its physiologic function in normal cells is unclear. In this study, by using drs knockout (KO) mouse embryonic fibroblast cells, we found that genetic loss of drs induces the metabolic shift toward aerobic glycolysis by increasing the expression and activity of lactose dehydrogenase (LDH). It is suggested that drs participates in the regulation of glucose metabolism and down-regulation of drs during tumorigenesis is involved in the induction of Warburg effect in human cancers. We also found that the induction of drs into KO cells and the treatment of cancer cells with LDH inhibitor could suppress the metabolic shift and the malignant transformation. Further investigations will contribute toward developing a new anticancer therapy.