Characterization of parasite's molecules specifying host-parasite relationship

基于我以前的证据，即唾液酸与粘蛋白的连接与胃肠道线虫巴西尼波斯特罗线虫从小鼠体内的排出有关，以及在蠕虫建立时存在少量唾液粘蛋白，我试图表征蠕虫上表达的影响建立/排出的配体分子，特别是唾液粘蛋白的配体分子。未检测到蠕虫对唾液粘蛋白的定向特征。唾液粘蛋白配体的表征仍在进行中。用凝集素阵列和MALDI-TOF-MS对粘蛋白糖基化的分析支持先前报道的结果。

Based on my previous evidences that linkage of sialic acid to mucins associates with expulsion of an gastrointestinal nematode, Nippostrongylus brasiliensis, from mice, and that existence of a small amount of sialomucin at the establishment of the worms, I tried to characterize ligand molecules expressed on the worms which affect the establishment/expulsion, especially those of sialomucin. No directional characteristic of the worms towards sialomucin was detected. Characterization of ligands of sialomucin is still going on. Analyses of glycosylation of mucins by the lectin-array and the MALDI-TOF-MS supported previously reported results.