Identification of low-molecular-mass secretory proteins of Mycobacterium tuberculosis and the application to development of anti-tuberculosis vaccines
Identification of low-molecular-mass secretory proteins of Mycobacterium tuberculosis and the application to development of anti-tuberculosis vaccines
批准号:
20590438
负责人:
NAGATA Toshi
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We identified here murine and human dominant T-cell epitopes of three low-molecular-mass secretory proteins, CFP11 (Rv2433c), CFP17 (Rv1827), TB18.5 (Rv0164) of Mycobacterium tuberculosis. Plasmid DNAs encoding these proteins were immunized to two inbred mice and HLA-DRB1^*0401 transgenic mice. T-cell epitopes were determined based on IFN-γ production from immune spleen cells. The results obtained here is feasible for analysis of the role of antigen-specific T cells during M.tuberculosis infection and the vaccine development.
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Characterization of murine T-cell epitopes on mycobacterial DNA-binding 1(MDP 1)using DNA vaccination.
使用 DNA 疫苗接种来表征分枝杆菌 DNA 结合 1 (MDP 1) 上的鼠 T 细胞表位。
DOI:
--
发表时间:
2010
期刊:
Vaccine 28
影响因子:
--
作者:
[Suzuki D, Nagata T, Ewda G, Matsumoto S, Matsumoto M, Tsuiimura K, Koide Y]
通讯作者:
Koide Y
MIP-1αと結核菌MPT51融合型DNAワクチンは抗原特異的CD8^+ T細胞を強く誘導する
MIP-1α和结核分枝杆菌MPT51融合DNA疫苗强烈诱导抗原特异性CD8^+ T细胞
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[内嶋雅人, 永田年, 辻村邦夫, 小出幸夫]
通讯作者:
小出幸夫
Characterization of murine T-cell epitopes in mycobacterial DNA-binding protein 1
分枝杆菌 DNA 结合蛋白 1 中小鼠 T 细胞表位的表征
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Suzuki D, Nagata T, Matsumoto S, Koide Y.]
通讯作者:
Koide Y.
Identification of murine T-cell epitopes on low-molecular-mass secreted proteins of Mycobacterium tuberculosis. Keystone Symposia, Tuberculosis
结核分枝杆菌低分子量分泌蛋白上鼠 T 细胞表位的鉴定。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nagata T, Eweda G, Suzuki D, Tsuiimura K, Koide Y]
通讯作者:
Koide Y
Induction of specific CD8+ Tcells against intracellular bacteria by CD8+ T-cell-oriented immunzation approaches.
通过 CD8 T 细胞定向免疫方法诱导针对细胞内细菌的特异性 CD8 T 细胞。
DOI:
--
发表时间:
2010
期刊:
J Biomed Biotechnol
影响因子:
--
作者:
[Nagata T, Koide Y]
通讯作者:
Koide Y
共 41 条
Evaluation of the mechanisms underlying carbon cycles mediated by microbial food web networks in meso- and bathypelagic layers of the oceans
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批准号:24241003
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项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$28.95万
-
财政年份:2012
-
负责人:NAGATA Toshi
-
依托单位:
Dynamic Control of Molecular Functions via Time-Dependent External Stimuli
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批准号:22550133
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
-
财政年份:2010
-
负责人:NAGATA Toshi
-
依托单位:
Evaluation of mechanisms underlying the formation of viral hot spot observed in the mid latitude region of the North Pacific
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批准号:22651004
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.27万
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财政年份:2010
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负责人:NAGATA Toshi
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依托单位:
Resource Recycling of Carbon Dioxide with Catalysis by Heteromultinuclear Metal Complexes
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批准号:21200057
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项目类别:Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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资助金额:$19.39万
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财政年份:2009
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负责人:NAGATA Toshi
-
依托单位:
Analyses of the dynamic structure of organic matter-bacteria interactions that mediate carbon cycling in meso- and bathypelagic oceans
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批准号:20310010
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2008
-
负责人:NAGATA Toshi
-
依托单位:
Construction of molecular systems for photosynthetic chemical conversion by artificial quinone pools
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批准号:19550173
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2007
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负责人:NAGATA Toshi
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依托单位:
Microbial and geochemical mechanisms controlling dissolution processes of particulate organic matter in the oceans
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批准号:17201004
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项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$21.96万
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财政年份:2005
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负责人:NAGATA Toshi
-
依托单位:
Identification of human T-cell epitopes on Mycobacterium tuberculosis small molecular weight proteins and development of DNA vaccines based on the epitopes
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批准号:16390130
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.96万
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财政年份:2004
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负责人:NAGATA Toshi
-
依托单位:
Study on anti-tuburculosis DNA vaccines using attenuated Listeria strain as the carrier
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批准号:14570234
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2002
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负责人:NAGATA Toshi
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依托单位:
Biocomplexity of the interactions of complex organic colloids and microbial communities in aquatic environments
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批准号:13308029
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.45万
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财政年份:2001
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负责人:NAGATA Toshi
-
依托单位:
Limnological properties of large lakes in eastern Asia under the influence of climate change
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批准号:13575034
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.85万
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财政年份:2001
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负责人:NAGATA Toshi
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依托单位:
Japan-U.S. Collaborative Research on the Biocomplexity of Colloidal Systems in Aquatic Environments
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批准号:12800016
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项目类别:Grant-in-Aid for Special Purposes
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资助金额:$12.16万
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财政年份:2000
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负责人:NAGATA Toshi
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依托单位:
DEVELOPMENT OF DNA VACCINES WHICH INDUCE DELAYED-TYPE CELLULAR IMMUNITY
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批准号:11670260
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1999
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负责人:NAGATA Toshi
-
依托单位:
Preservation of dissoloved organic matter in the Ocean
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批准号:11694197
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$3.14万
-
财政年份:1999
-
负责人:NAGATA Toshi
-
依托单位:
The phase transition of ecosystem structure in the upper ocean
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批准号:10480125
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.72万
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财政年份:1998
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负责人:NAGATA Toshi
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依托单位:
Metabolic control of dissolved organic matter dynamics
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批准号:09044207
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$6.46万
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财政年份:1997
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负责人:NAGATA Toshi
-
依托单位:
Degradation of Collidal Organic Matter in Seawater
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批准号:08458142
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.35万
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财政年份:1996
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负责人:NAGATA Toshi
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依托单位:
Microbial metabolic processes that control the dynamics of high-molecular-weight dissolved organic matter in the ocean
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批准号:06680489
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.54万
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财政年份:1994
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负责人:NAGATA Toshi
-
依托单位:
海外基金