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Identification of low-molecular-mass secretory proteins of Mycobacterium tuberculosis and the application to development of anti-tuberculosis vaccines

Identification of low-molecular-mass secretory proteins of Mycobacterium tuberculosis and the application to development of anti-tuberculosis vaccines
结核分枝杆菌低分子量分泌蛋白的鉴定及其在抗结核疫苗研制中的应用
批准号:
20590438
负责人:
NAGATA Toshi
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
We identified here murine and human dominant T-cell epitopes of three low-molecular-mass secretory proteins, CFP11 (Rv2433c), CFP17 (Rv1827), TB18.5 (Rv0164) of Mycobacterium tuberculosis. Plasmid DNAs encoding these proteins were immunized to two inbred mice and HLA-DRB1^*0401 transgenic mice. T-cell epitopes were determined based on IFN-γ production from immune spleen cells. The results obtained here is feasible for analysis of the role of antigen-specific T cells during M.tuberculosis infection and the vaccine development.
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Characterization of murine T-cell epitopes on mycobacterial DNA-binding 1(MDP 1)using DNA vaccination.
使用 DNA 疫苗接种来表征分枝杆菌 DNA 结合 1 (MDP 1) 上的鼠 T 细胞表位。
DOI: --
发表时间: 2010
期刊: Vaccine 28
影响因子: --
作者: [Suzuki D, Nagata T, Ewda G, Matsumoto S, Matsumoto M, Tsuiimura K, Koide Y]
通讯作者: Koide Y
MIP-1αと結核菌MPT51融合型DNAワクチンは抗原特異的CD8^+ T細胞を強く誘導する
MIP-1α和结核分枝杆菌MPT51融合DNA疫苗强烈诱导抗原特异性CD8^+ T细胞
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [内嶋雅人, 永田年, 辻村邦夫, 小出幸夫]
通讯作者: 小出幸夫
Characterization of murine T-cell epitopes in mycobacterial DNA-binding protein 1
分枝杆菌 DNA 结合蛋白 1 中小鼠 T 细胞表位的表征
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Suzuki D, Nagata T, Matsumoto S, Koide Y.]
通讯作者: Koide Y.
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Nagata T, Eweda G, Suzuki D, Tsuiimura K, Koide Y]
通讯作者: Koide Y
41
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    • 批准号:
      24241003
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $28.95万
    • 财政年份:
      2012
    • 负责人:
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    • 依托单位:
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    • 项目类别:
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    • 资助金额:
      $3.0万
    • 财政年份:
      2010
    • 负责人:
      NAGATA Toshi
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      22651004
    • 项目类别:
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      $2.27万
    • 财政年份:
      2010
    • 负责人:
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    • 批准号:
      21200057
    • 项目类别:
      Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
    • 资助金额:
      $19.39万
    • 财政年份:
      2009
    • 负责人:
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    • 依托单位:
    海外基金