Establishment of a novel vaccine against Mycobacterium tuberculosis employing carbohydrate-coated liposomes

利用碳水化合物包被的脂质体建立抗结核分枝杆菌的新型疫苗

• 批准号: 20590439
• 负责人: TSUJIMURA Kunio
• 金额: $ 3.08万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590439/
• 关键词: ワクチン; 結核菌; 糖鎖; リポソーム; 結核; オリゴマンノース; Th1

A novel vaccine against Mycobacterium tuberculosis was established employing a tuberculosis-protective antigen MPT51 and oligomannose-coated liposomes. Antigen-specific T-cell responses and antibody production were effectively induced in mice vaccinated with this composition. In addition, induced cytokine profiles and antibody classes suggested that this newly formulated vaccine could elicit Th1-type immune responses known to be important for the protection against tuberculosis.

采用结核保护性抗原MPT 51和低聚甘露糖包被的脂质体构建了一种新型结核分枝杆菌疫苗。在用该组合物接种的小鼠中有效地诱导抗原特异性T细胞应答和抗体产生。此外，诱导的细胞因子谱和抗体类别表明，这种新配制的疫苗可以引发已知对预防结核病重要的Th1型免疫应答。

项目成果

Cancer vaccine delivery using oligomannose coated liposomes

使用寡甘露糖包被的脂质体递送癌症疫苗

• 发表时间: 2009
• 作者: Ikehara Y;et al.
• 通讯作者: et al.

Mycobacterium tuberculosis modulates the network of Rab GTPases in attenuation of phagosome maturation.

结核分枝杆菌通过调节 Rab GTPases 网络来减弱吞噬体的成熟。

• 发表时间: 2009
• 作者: Seto S;Koide Y
• 通讯作者: Koide Y

Identification of HLA-DR4-restricted T-cell epitope on MPT51 protein, a major secreted protein derived from Mycobacterium tuberculosis using MPT51 overlapping peptides screening.

使用 MPT51 重叠肽筛选鉴定 MPT51 蛋白（一种源自结核分枝杆菌的主要分泌蛋白）上的 HLA-DR4 限制性 T 细胞表位。

• 发表时间: 2008
• 作者: Nagata T;Wang L-X;Koide Y
• 通讯作者: Koide Y

Chemokine receptor-mediated delivery of mycobacterial MPT51 protein efficiently induced antigen-specific T-cell responses.

趋化因子受体介导的分枝杆菌 MPT51 蛋白递送有效诱导抗原特异性 T 细胞反应。

• 发表时间: 2008
• 期刊: Vaccine 26
• 作者: Masato Uchijima;et al.
• 通讯作者: et al.

Live Mycobacterium tuberculosis inhibits phagolysosome biogenesis in macrophages by modulating localization of Rab GTPase proteins on its phagosomes.

活结核分枝杆菌通过调节 Rab GTPase 蛋白在其吞噬体上的定位来抑制巨噬细胞中吞噬溶酶体的生物发生。

• 发表时间: 2008
• 作者: Shintaro Seto;et al.
• 通讯作者: et al.