Role of macrophage in Helicobacter pylori infection

早期胃癌幽门螺杆菌感染患者巨噬细胞抗原摄取受体DEC205表达升高。而非胃癌患者DEC205 mRNA表达也明显升高。用HSP60刺激胃癌患者淋巴细胞，检测Th1细胞因子的表达。HSP60刺激及其对T辅助性CD4的反应可能有助于幽门螺杆菌感染引起的胃癌的诊断或预测。另一方面，HSP60抗体可能与幽门螺杆菌感染引起的心血管疾病（CVD）有关。

Expression of DEC205, which is antigen uptake receptor on macrophage, was increased in H.pylori infected patients with early gastric cancer. However mRNA of DEC205 was also increased in the patient without gastric cancer. Expression of Th1 cytokines was detected in lymphocyte stimulated with HSP60 from patients with gastric cancer. HSP60 stimulation and its response in T helper CD4 may be available for diagnosis or prediction of gastric cancer caused by H.pylori infection. On the other hand, HSP60 antibody may be associated with cardiovascular disease (CVD) induced by H.pylori infection.