Molecular biology and epidemiological analysis of Ent plasmid transmission in Enterotoxigenic Escherichia coli.

对产肠毒素大肠杆菌H10407中的Ent质粒(PEntH10407)进行了核苷酸全序列测定。序列分析表明，pEntH10407包含三个不同的主要区域：(I)含有肠毒素基因的致病胰岛；(Ii)与质粒复制和维持有关的区域；(Iii)包括导致自传的trA基因的区域。这增加了H10407毒株可能是通过pEntH10407的自我传播而产生的可能性。

The complete nucleotide sequence was determined for an Ent plasmid (pEntH10407) in enterotoxigenic Escherichia coli H10407. Sequence analysis indicated that pEntH10407 contains three distinct major regions: (i) a pathogenicity islet containing enterotoxin genes, (ii) a region involved in plasmid replication and maintenance, and (iii) a region including tra genes that cause the self-transmissibility. This raises possibility that the H10407 strain might have been born by self-transmissibility of pEntH10407.