The role of CM2 ion channel protein in influenza C virus replication and pathogenesis

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Quantification of vRNA in the VLPs by real-time PCR revealed that the CM2-deficient VLPs contain approximately one-third of the vRNA found in wild-type VLPs, suggesting that CM2 is involved in the genome packaging process into VLPs. Furthermore, a smaller amount of vRNA was detected in the nuclear fraction of CM2-deficient VLP-infected cells than in that of wild-type VLP-infected cells, suggesting that the uncoating process of the CM2-deficient VLPs in the infected cells did not proceed in an appropriate manner. Taken together, it is suggested that CM2 has a potential role in the genome packaging and uncoating processes of the virus replication.