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Analysis on the roles of PLCγ2 in generation and maintenance of immunological memory

Analysis on the roles of PLCγ2 in generation and maintenance of immunological memory
PLCγ2在免疫记忆生成和维持中的作用分析
批准号:
20590497
负责人:
HIKIDA Masaki
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
In spite of previous researches, molecular basis for the development and survival of memory B cells remains largely unknown. In this study, we tried to clarify the roles of PLCγ2 on such molecular machinery. As the result, we found that PLCγ2 is playing a pivotal role in the formation of germinal center, where memory B cells are formed. It was also revealed that PLCγ2 is essential for the maintenance of the memory B cells.
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PLC-γ2 is essential for formation and maintenance of memory B cells.
PLC-γ2 对于记忆 B 细胞的形成和维持至关重要。
DOI: --
发表时间: 2009
期刊: J.Exp.Med. 206(3)
影响因子: --
作者: [Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T.]
通讯作者: Kurosaki T.
PLCγ2 is essential for formation and maintenance of memory B cells.
PLCγ2 对于记忆 B 细胞的形成和维持至关重要。
DOI: --
发表时间: 2009
期刊: J. Exp. Med. 206
影响因子: --
作者: [Hikida M., Casola S., Takahashi N., Kaji T., Takemori T., Rajewsky K., Kurosaki T.]
通讯作者: Kurosaki T.
PLCγ2 is essential for formation and maitenance of memory B cells
PLCγ2 对于记忆 B 细胞的形成和维持至关重要
DOI: --
发表时间: 2009
期刊: J. Exp. Med. vol 206
影响因子: --
作者: [Nakayama, M., 疋田正喜]
通讯作者: 疋田正喜
Essential roles of mgcRacGAP in multilineage differentiation and survival of murine hematopoietic cells.
mgcRacGAP 在小鼠造血细胞的多谱系分化和存活中的重要作用。
DOI: --
发表时间: 2008
期刊: Biochem. Biophys. Res. Commun. 372
影响因子: --
作者: [Yamada T., Kurosaki T., Hikida M.]
通讯作者: Hikida M.
6
    Analyses on novel selection and regulatory mechanisms of IgG-positive memory B cells
    • 批准号:
      19K07618
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2019
    • 负责人:
      HIKIDA Masaki
    • 依托单位:
    Analysis on regulatory mechanism of B cell selection by novel signaling molecule in germinal center
    • 批准号:
      23590568
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2011
    • 负责人:
      HIKIDA Masaki
    • 依托单位:
    Regulation of auto-reactive B cell activation by Ras signaling pathway
    Roles of BCR signaling mediated by PLC-γ2 on memory response
    • 批准号:
      16590414
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2004
    • 负责人:
      HIKIDA Masaki
    • 依托单位:
    海外基金