Analysis on the roles of PLCγ2 in generation and maintenance of immunological memory
Analysis on the roles of PLCγ2 in generation and maintenance of immunological memory
批准号:
20590497
负责人:
HIKIDA Masaki
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
In spite of previous researches, molecular basis for the development and survival of memory B cells remains largely unknown. In this study, we tried to clarify the roles of PLCγ2 on such molecular machinery. As the result, we found that PLCγ2 is playing a pivotal role in the formation of germinal center, where memory B cells are formed. It was also revealed that PLCγ2 is essential for the maintenance of the memory B cells.
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PLC-γ2 is essential for formation and maintenance of memory B cells.
PLC-γ2 对于记忆 B 细胞的形成和维持至关重要。
DOI:
--
发表时间:
2009
期刊:
J.Exp.Med. 206(3)
影响因子:
--
作者:
[Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T.]
通讯作者:
Kurosaki T.
PLCγ2 is essential for formation and maintenance of memory B cells.
PLCγ2 对于记忆 B 细胞的形成和维持至关重要。
DOI:
--
发表时间:
2009
期刊:
J. Exp. Med. 206
影响因子:
--
作者:
[Hikida M., Casola S., Takahashi N., Kaji T., Takemori T., Rajewsky K., Kurosaki T.]
通讯作者:
Kurosaki T.
PLCγ2 is essential for formation and maitenance of memory B cells
PLCγ2 对于记忆 B 细胞的形成和维持至关重要
DOI:
--
发表时间:
2009
期刊:
J. Exp. Med. vol 206
影响因子:
--
作者:
[Nakayama, M., 疋田正喜]
通讯作者:
疋田正喜
Essential roles of mgcRacGAP in multilineage differentiation and survival of murine hematopoietic cells.
mgcRacGAP 在小鼠造血细胞的多谱系分化和存活中的重要作用。
DOI:
--
发表时间:
2008
期刊:
Biochem. Biophys. Res. Commun. 372
影响因子:
--
作者:
[Yamada T., Kurosaki T., Hikida M.]
通讯作者:
Hikida M.
IgG1 memory B cell compartment undergoes qualitative alteration after its initial generation early in the immune response
IgG1 记忆 B 细胞区室在免疫反应早期初始生成后经历了质的改变
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[疋田正喜, 他4名]
通讯作者:
他4名
共 6 条
Analyses on novel selection and regulatory mechanisms of IgG-positive memory B cells
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批准号:19K07618
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2019
-
负责人:HIKIDA Masaki
-
依托单位:
Analysis on regulatory mechanism of B cell selection by novel signaling molecule in germinal center
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批准号:23590568
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
-
财政年份:2011
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负责人:HIKIDA Masaki
-
依托单位:
Regulation of auto-reactive B cell activation by Ras signaling pathway
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批准号:18590479
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
-
财政年份:2006
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负责人:HIKIDA Masaki
-
依托单位:
Roles of BCR signaling mediated by PLC-γ2 on memory response
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批准号:16590414
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2004
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负责人:HIKIDA Masaki
-
依托单位:
Visualization of alteration of antigen specificity in mature B lymphocytes by multiple fluorescent labelling
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批准号:12650789
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.77万
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财政年份:2000
-
负责人:HIKIDA Masaki
-
依托单位:
海外基金