Analysis on regulatory mechanism of B cell selection by novel signaling molecule in germinal center

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We have found that a subset of germinal center B cells is expressing CD3e, which have been widely known as a T cell-specific signaling molecule. The germinal center B cells we have observed were proliferating cells and we have also observed that CD3e is involved in apoptosis of these B cells. These results suggest that still unknown molecules are playing essential roles in positive and/or negative selection in the germinal center B cells. Also, we have found that this cell number of this population was increased in a autoimmune-prone model mice strain compared to the wild type mice. This may suggest the involvement of this population in autoimmune diseases.