Role of Notch in the pathophysiology of leukemia stem cells and drug sensitivity tests for Notch inhibitors

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In order to treat leukemia effectively, we have to understand the pathophysiology of leukemia stem cells. Notch signaling is important for the regulation of self-renewal of leukemia stem cells. We found the molecular mechanism how the Notch ligand stimulation activates the Notch signaling and how it leads to cell growth. Moreover, we found that gamma-secretase inhibitors, which inhibit Notch signaling, suppress the growth of leukemia cells. We developed the methods to predict its effects.