Study on pathogenesis of pneumoconiosis by exposure to igusa-sendo and diatomite dust and its prevention

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To understand pathogenic mechanism of pneumoconiosis due to igusa sendo and diatomite we performed experimental research and environmental study. Macrophage increase in number in the BALF from the animals exposed to igusa send, but it would die or decompose due to the digested diatomite in it. 2-ethylhexyl-4-methoxycinnamate does not provoke contact dermatitis as the usual concentration in commercial cosmetics. Not only wearing wide brimmed hat, but also making up with suntan lotion are thought to be useful measures against sunstroke in igusa planting field. During the environmental study, we find that there are some work places where they weave igusa not treated with muddy sendo soil to make tatami matt. It is understood that the weaving method is the best way to measure the igusa-send dust exposure.