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建設作業に伴う石綿曝露がもたらす肺癌・中皮腫リスク増を観察するコホート研究

队列研究观察与建筑工作相关的石棉暴露导致肺癌和间皮瘤风险增加

基本信息

批准号：
20590617
负责人：
柴田英治
金额：
$ 1.33万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590617/
关键词：
石綿建設労働者解体胸膜肥厚斑肺癌中皮腫胃癌

项目摘要

【背景・目的】多種多様な危険有害因子に曝露され、一人親方や小規模事業所労働者の比率が高く、労働安全衛生対策が十分とは言い難い建設作業者にいて、その死因と石綿曝露・喫煙歴・飲酒習慣との関係を検討した。【対象】三重県の建設国民健康保険組合(2005年3月現在、組合員16,616名)の男性組合員本人で2001年1月〜2005年12月に死亡した324人及び建設業の職歴を有する組合員家族6人、計330人(20〜89歳)。【方法】対象者が死亡した際に家族から同組合に提出された葬祭費支給申請書、死亡診断書、喫煙歴・飲酒歴に関する問診票と国民健康保険診療報酬請求書明細書から、死亡の年齢、死亡年月日、死因、喫煙歴、飲酒歴などを得て、ICD-10に基づく死因の分類を行った。職種別の解析は組合加入時の登録に基づいた。2003年人口動態統計記載の全国男性の原因別死亡者数を標準集団として、標準化比例死亡比(SPMR)を、(1)全死亡者、(2)石綿によると推測される胸部X線写真上の胸膜肥厚斑の有所見率の高低で分類した職種群、(3)喫煙の有無別、(4)飲酒習慣の有無別、(5)職種群分類&喫煙の有無、(6)職種群分類&飲酒の有無別に算出した。胸膜肥厚斑頻度は我々のこれまでの調査で、頻度が2%超の職種と、2%以下の職種の2群に分類した。本研究は主解析者所属機関の研究倫理委員会の承認を得て行った。【結果および考察】全悪性新生物、肺癌、胃癌のSPMRが有意に上昇した。1973年〜1993年の死亡者について我々が行ったSPMR調査と比較すると、不慮の事故での有意差が新たに認められた。また、胃癌・肺癌に関しては、胸膜肥厚斑有所見率の高い群において、喫煙が加わることによりさらにSPMRの値が上昇した。石綿への曝露により、肺癌だけでなく胃癌での死亡も増加する可能性が示された。

【Background・Purpose】The risk of exposure to a variety of dangerous harmful factors, the high ratio of workers in small-scale establishments with one person, and the safety of The health policy is very difficult to explain, and the cause of death is related to asbestos exposure, smoking habits, and drinking habits among construction workers. [Tai Xiang] The male member of Mie Prefecture's National Health Insurance Group (as of March 2005, 16,616 members), 2001 From January to December 2005, 324 people died, and there were 6 family members working in the construction industry, totaling 330 people (20 to 89 years old). [Method] If the person who has died is a member of the same family or group, submit an application form for payment of funeral expenses, a death diagnosis certificate, a medical check-up ticket for smoking and drinking, and a National Health Insurance Details of request for medical treatment reimbursement, year of death, date of death, cause of death, cigarette smoking, alcohol consumption, ICD-10 classification of cause of death. The analysis of job categories and the registration when joining a combination are based on the basics. 2003 Vital Statistics records the number of male deaths by cause nationwide, standard collection, standardized proportional mortality ratio (SPMR), (1) total deaths, (2) asbestos speculation, chest X-ray photo The high and low rate of visible pleural hypertrophy spots can be classified into occupational groups, (3) whether there is any difference in smoking habits, (4) whether there is any difference in drinking habits, (5) occupational group classification & whether there is any difference in smoking, (6) occupational group classification & whether there is any difference in drinking habits, and it can be calculated. The frequency of pleural hypertrophy spots is investigated, the frequency is more than 2%, and the frequency is less than 2%, and the frequency is classified into 2 groups. This study was approved by the Research Ethics Committee of the institution to which the main analyst belongs. [Results Survey] SPMR of all new organisms, lung cancer, and gastric cancer has increased significantly. From 1973 to 1993, the deceased persons were investigated and compared with SPMR, and the accidents and accidents were not taken into account, and the new ones were recognized and recognized.また, gastric cancer, lung cancer に关しては, pleural hypertrophy spots with a high incidence rate, cigarette smoking が加わることによりさらにSPMR の値がRISE した. Asbestos exposure is a concern, lung cancer is a concern, and gastric cancer is a cause of death.