Understanding the mechanism of liver carcinogenesis and strategy for the prevention of hepatoma development

了解肝癌发生机制及预防肝癌发展的策略

• 批准号: 20590615
• 负责人: WATANABE Tetsu
• 金额: $ 3.08万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590615/
• 关键词: 予防医学; 脂肪肝; 肝発癌; 酪酸菌

The CDAA diet induced NASH in Fisher rats, characerized by steatois, ilammation, fibrosis, and cirrosis in the liver. Serum level of endotoxin in the portal vein and lipoperoxidation in the liver were observe at 2 month of CDAA diet. On the contrary, treatment of rats with Clostridium butyricum in CDAA diet markedly improved liver fibrosis and lowered the level of endotoxin and GST-P. Alteration of the intestinal flora and butyrate produced by Clostridium butyricum may involve in these protective response to the NASH progression.

CDAA饮食在Fisher大鼠中诱导NASH，其特征在于肝脏中的脂肪变性、炎症、纤维化和硬化。观察CDAA饮食2个月时门静脉血内毒素水平和肝脏脂质过氧化水平。与此相反，在CDAA饲料中添加丁酸梭菌可显著改善大鼠的肝纤维化，降低内毒素和GST-P水平。丁酸梭菌对NASH的保护作用可能与其对肠道植物群和丁酸盐的影响有关。

项目成果

Eight-week oral administration of meloxicam,a non-steroidal anti-inflammatory drug,prevents dose reduction of pegylated interferon alpha-2a in the treatment of chronic hepatitis C

口服非甾体抗炎药美洛昔康八周可防止聚乙二醇干扰素α-2a治疗慢性丙型肝炎的剂量减少

• 发表时间: 2008
• 期刊: Hepatology Research 38
• 作者: Kagawa T;et. al.
• 通讯作者: et. al.

Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma

经导管动脉化疗栓塞联合射频消融治疗早期肝细胞癌

• 发表时间: 2010
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Kakinuma M;Takahashi M;Kato N;Aratake Y;Watanabe M;Ishikawa Y;Kojima R;Shibaoka M;Tanaka K.;今任拓也;Kagawa T
• 通讯作者: Kagawa T

Activation of distinct MAPK pathways governs constitutive expression of two matrix metalloproteinase-lin human pancreatic cancer cell lines.

不同 MAPK 途径的激活控制两种基质金属蛋白酶-lin 人胰腺癌细胞系的组成型表达。

• 发表时间: 2009
• 期刊: Int J Oncology 35
• 作者: Endo H;Watanabe T;Sugioka Y;Niioka M;Inagaki Y;Okazaki I
• 通讯作者: Okazaki I

Metabolic syndrome progression in young japanese workers in a selected company.

一家选定公司的年轻日本工人代谢综合征的进展。

• 发表时间: 2009
• 作者: Yu H-S;Oyama T;Matsuda T;Isse T;Yamaguchi T;Tanaka M;Tsuji M;Kawamoto T;Oyama T;Billah SMB
• 通讯作者: Billah SMB

Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma.

经导管动脉化疗栓塞联合射频消融治疗早期肝细胞癌。

• 发表时间: 2010
• 期刊: Cancer 116
• 作者: Tatehiro Kagawa;Jun Koizumi;Sei-ichiro Kojima;Naruhiko Nagata;Makoto Numata;Norihito Watanabe;Tetsu Watanabe;Tetsuya Mine
• 通讯作者: Tetsuya Mine