Therapeutic inhibition of microRNA-34a ameliorates aortic valve calcification via modulation of Notch1-Runx2 signaling

microRNA-34a 的治疗性抑制通过调节 Notch1-Runx2 信号传导改善主动脉瓣钙化

• 批准号: 16K09490
• 负责人: WATANABE Tetsu
• 金额: $ 3.08万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09490/
• 关键词: 石灰化大動脈弁狭窄症; micro RNA; Notch1; Runx2; ワイヤー傷害; 大動脈弁狭窄症; 石灰化; Micro RNA; microRNA

项目成果

Therapeutic inhibition of microRNA-34a ameliorates aortic valve calcification via modulation of Notch1-Runx2 signaling in calcific aortic valve stenosis model mice by direct wire injury

在钙化主动脉瓣狭窄模型小鼠中，通过直接线损伤调节 Notch1-Runx2 信号传导，治疗性抑制 microRNA-34a 可改善主动脉瓣钙化

• 发表时间: 2018
• 作者: Taku Toshima;Tetsu Watanabe;Tetsuro Shishido;Takuya Miyamoto;Tetsuya Takahashi Takayuki Sugai;Ken Watanabe;Jun Goto;Isao Kubota and Masafumi Watanabe
• 通讯作者: Isao Kubota and Masafumi Watanabe

Silencing of microRNA-34a ameliorates aortic valve calcification via Notch1-Runx2 signaling in vivo and in vitro experiments

体内和体外实验中 microRNA-34a 的沉默可通过 Notch1-Runx2 信号传导改善主动脉瓣钙化

• 发表时间: 2018
• 作者: Taku Toshima;Tetsu Watanabe;Tetsuro Shishido;Takuya Miyamoto;Takanori Arimoto;Hiroki Takahashi;Mitsuaki Sadahiro;Isao Kubota;and Masafumi Watanabe
• 通讯作者: and Masafumi Watanabe

Inhibition of MicroRNA-34a Attenuates Osteogenic Differentiation via Inhibiting Notch1 Signal in Aortic Valve Interstitial Cells

抑制 MicroRNA-34a 通过抑制主动脉瓣间质细胞中的 Notch1 信号来减弱成骨分化

• 发表时间: 2017
• 作者: Toshima T;Watanabe T;Shishido T;Watanabe K;Sugai T;Takahashi T;Tamura H;Nishiyama S;Arimoto T;Takahashi H;Kubota I
• 通讯作者: Kubota I