A role of Maf B in development and rupture of atherosclerotic plaques

Maf B 在动脉粥样硬化斑块的形成和破裂中的作用

• 批准号: 21790700
• 负责人: WATANABE Tetsu
• 金额: $ 2.75万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790700/
• 关键词: 動脈硬化; マクロファージ; プラーク破綻; MafB

There was no difference in development of atherosclerotic plaques between ApoE-/-and DN-MafB/ApoE-/-mice. However, more necrotic cores and fewer fibrous tissues were shown in atherosclerotic plaques in DN-MafB/ApoE-/-mice than in ApoE-/-mice. DN-MafB/ApoE-/-mice had more apoptotic macrophages and production of reactive oxygen species in the atherosclerotic plaques than ApoE-/-mice. DN-MafB may be associated with vulnerability of atherosclerotic plaques.

ApoE-/-和DN-MafB/ApoE-/-小鼠在动脉粥样硬化斑块形成方面无明显差异。与ApoE-/-鼠相比，DN-MafB/ApoE-/-鼠动脉粥样硬化斑块中的坏死核较多，纤维组织较少。Dn-MafB/ApoE-/-小鼠较ApoE-/-小鼠有更多的巨噬细胞凋亡和动脉粥样硬化斑块中活性氧的产生。DN-MafB可能与动脉粥样硬化斑块的易损性有关。

项目成果

High variability of albuminuria in nondiabetic population: the Takahata Study

• DOI: 10.1007/s10157-009-0177-3
• 发表时间: 2009-10-01
• 期刊: CLINICAL AND EXPERIMENTAL NEPHROLOGY
• 影响因子: 2.3
• 作者: Suzuki, Kazuko;Konta, Tsuneo;Kubota, Isao
• 通讯作者: Kubota, Isao

8-Hydroxy-2′-deoxyguanosine is a prognostic mediator for cardiac event

• DOI: 10.1111/j.1365-2362.2010.02465.x
• 发表时间: 2011-07-01
• 期刊: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 5.5
• 作者: Suzuki, Satoshi;Shishido, Tetsuro;Kubota, Isao
• 通讯作者: Kubota, Isao

Serum Pregnancy-Associated Plasma Protein A in Patients With Heart Failure

• DOI: 10.1016/j.cardfail.2011.05.011
• 发表时间: 2011-10-01
• 期刊: JOURNAL OF CARDIAC FAILURE
• 影响因子: 6
• 作者: Funayama, Akira;Shishido, Tetsuro;Kubota, Isao
• 通讯作者: Kubota, Isao

Prognostic Value of Low Left Atrial Appendage Wall Velocity in Patients with Ischemic Stroke and AtrialFibrillation

左心耳壁流速低对缺血性卒中合并心房颤动患者的预后价值

• DOI: 10.1016/j.echo.2012.01.012
• 发表时间: 2012
• 期刊: J Am Soc Echocardiogr
• 作者: 谷口琢也、小形岳寛;他;Harutoshi Tamura
• 通讯作者: Harutoshi Tamura

Feasibility of combined evaluation of brain natriuretic peptide and heart-type fatty acid binding protein in female patients with heart failure.

脑钠肽和心型脂肪酸结合蛋白联合评价女性心力衰竭患者的可行性。

• 发表时间: 2010
• 作者: Funayama A;Shishido T;Netsu S;Ishino M;Otaki Y;Honda S;Hasegawa H;Kadowaki S;Narumi T;Nishiyama S;Takahashi H;Arimoto T;Miyashita T;Miyamoto T;Watanabe T;Woo CH;Kuwahara K;Nakao K;Takeishi Y;Kubota I;Hasegawa H
• 通讯作者: Hasegawa H