A role of Maf B in development and rupture of atherosclerotic plaques
A role of Maf B in development and rupture of atherosclerotic plaques
批准号:
21790700
负责人:
WATANABE Tetsu
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
在ApoE-/和DN-MafB/ApoE-/-小鼠之间,动脉粥样硬化斑块的发展没有差异。然而,与ApoE-/-小鼠相比,DN-MafB/ApoE-/-小鼠的动脉粥样硬化斑块中显示出更多的坏死核心和更少的纤维组织。DN-MafB/ApoE-/-小鼠比ApoE-/-小鼠在动脉粥样硬化斑块中有更多的凋亡巨噬细胞和活性氧的产生。DN-MafB可能与动脉粥样硬化斑块易感性有关。
英文摘要
There was no difference in development of atherosclerotic plaques between ApoE-/-and DN-MafB/ApoE-/-mice. However, more necrotic cores and fewer fibrous tissues were shown in atherosclerotic plaques in DN-MafB/ApoE-/-mice than in ApoE-/-mice. DN-MafB/ApoE-/-mice had more apoptotic macrophages and production of reactive oxygen species in the atherosclerotic plaques than ApoE-/-mice. DN-MafB may be associated with vulnerability of atherosclerotic plaques.
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DOI:
10.1007/s10157-009-0177-3
发表时间:
2009-10-01
期刊:
CLINICAL AND EXPERIMENTAL NEPHROLOGY
影响因子:
2.3
作者:
[Suzuki, Kazuko, Konta, Tsuneo, Kubota, Isao]
通讯作者:
Kubota, Isao
DOI:
10.1111/j.1365-2362.2010.02465.x
发表时间:
2011-07-01
期刊:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
影响因子:
5.5
作者:
[Suzuki, Satoshi, Shishido, Tetsuro, Kubota, Isao]
通讯作者:
Kubota, Isao
DOI:
10.1016/j.cardfail.2011.05.011
发表时间:
2011-10-01
期刊:
JOURNAL OF CARDIAC FAILURE
影响因子:
6
作者:
[Funayama, Akira, Shishido, Tetsuro, Kubota, Isao]
通讯作者:
Kubota, Isao
Prognostic Value of Low Left Atrial Appendage Wall Velocity in Patients with Ischemic Stroke and AtrialFibrillation
左心耳壁流速低对缺血性卒中合并心房颤动患者的预后价值
DOI:
10.1016/j.echo.2012.01.012
发表时间:
2012
期刊:
J Am Soc Echocardiogr
影响因子:
--
作者:
[谷口琢也、小形岳寛, 他, Harutoshi Tamura]
通讯作者:
Harutoshi Tamura
Feasibility of combined evaluation of brain natriuretic peptide and heart-type fatty acid binding protein in female patients with heart failure.
脑钠肽和心型脂肪酸结合蛋白联合评价女性心力衰竭患者的可行性。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Funayama A, Shishido T, Netsu S, Ishino M, Otaki Y, Honda S, Hasegawa H, Kadowaki S, Narumi T, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Woo CH, Kuwahara K, Nakao K, Takeishi Y, Kubota I, Hasegawa H]
通讯作者:
Hasegawa H
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海外基金