Elucidation of the development mechanism of the alcohol and aceta l dehyde-induced squamous-cell-carcinoma by using A/dh2 deficient mice.

可以简单地观察到外层皮肤。因此，我们对ALDH2缺陷小鼠皮下注射乙醛。ALDH2基因缺陷小鼠的背部皮肤发生鳞状细胞癌，我们对其进行了分子生物学和病理学检查。众所周知，ALDH2基因缺陷的个体因饮酒而发生口咽癌或食道癌的风险更大。我们将这一结果应用于医疗和癌症的预防。

The outer skin can be observed simply. Therefore we administered acetaldehyde to the Aldh2-deficient mice subcutaneously. Squamous cell carcinomas occurred on the back skins of the Aldh2--deficient mice and we examined them molecular biologically and pathologically.It is well known that the Aldh2-deficient individuals should have greater risks of the incidence of the oropharyngeal or the esophageal cancer by drinking.We apply this result to the medical treatment and the prevention of cancers.