Molecular-toxic and -pathological analyses for a synthetic narcotic, MDMA

合成麻醉品 MDMA 的分子毒性和病理学分析

• 批准号: 20590673
• 负责人: TAKAYASU Tatsunori
• 金额: $ 3.08万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590673/
• 关键词: MDMA; 合成麻薬; 分子レベル; 毒性機構; 細胞レベル; 個体レベル; 合成; 麻薬; 分子; 病態解析; 毒性機序

In this study on toxicity of cell level and animals with MDMA, mRNA analyses in the brain, heart and liver of the mouse, serum ALT analysis of the heart blood, and toxicological analysis of MDMA in the heart blood are comprehensively analyzed. MDMA concentrations of heart blood in the mouse with abnormal action were lower than those added in the culture cells which had abnormal. MDMA lethal level in the blood of the mouse was about 1/2 level of that in the abnormal cells. In MDMA dose of 40 mg/kg body weight, inflammation in the liver was suggested by the analyses of mRNA factors and serum ALT level.

在细胞水平和动物毒性研究中，对MDMA在小鼠脑、心、肝组织中的mRNA分析、心脏血液中的血清ALT分析以及MDMA在心脏血液中的毒理学分析进行了综合分析。行为异常的小鼠心脏血中MDMA浓度低于培养细胞中加入的MDMA浓度。小鼠血液中MDMA致死水平约为异常细胞中MDMA致死水平的1/2。在MDMA剂量为40 mg/kg体重时，通过对mRNA因子和血清ALT水平的分析，发现肝脏有炎症反应。