Comprehensive analysis for biological toxicity with synthetic narcotic MDMA

合成麻醉性摇头丸生物毒性综合分析

• 批准号: 23590845
• 负责人: TAKAYASU Tatsunori
• 金额: $ 3.33万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590845/
• 关键词: 合成麻薬; MDMA; 毒性; 遺伝子; 多因子解析; 覚せい剤; 覚醒剤

MDMA is a synthetic narcotic, which is resembled to methamphetamine (MA) structure. The aim of this study is clear the differences of biological functions from MDMA and MA. MDMA and MA were separately injected to mice once two days during 51 days as well as saline for a blank experiment. Mice weights for MDMA or MA were decreased to those of a blank group for 10-20 days. Then mice weights for MDMA and MA were increased same rate as the blank group. Comprehensive mRNA analyses with the brain and heart showed changes of metabolic factors for lipids and fatty acids, cytokines, transcription factors, translations factors, and others. These results are fundamental to the next experiment.

MDMA是一种与甲基苯丙胺（MA）结构相似的人工合成麻醉剂。本研究的目的是明确MDMA和MA的生物学功能差异。MDMA和MA分别注射给小鼠，51天内两天一次，以及生理盐水作为空白实验。将MDMA或MA的小鼠体重降低至空白组的体重，持续10-20天。MDMA组和MA组小鼠体重以与空白组相同的速度增加。大脑和心脏的全面mRNA分析显示脂质和脂肪酸、细胞因子、转录因子、翻译因子等代谢因子的变化。这些结果是下一个实验的基础。

项目成果

マウスにおけるMDMA投与時の各種因子の動態

小鼠MDMA给药过程中各因素的动态变化

• 发表时间: 2013
• 作者: Hiroki Hayashi;Kunihiro Nishimura;Shouichi Maruyama;Yukio Yuzawa;西村邦宏;西村 邦宏;高安達典
• 通讯作者: 高安達典