Research on the mechanism of alcohol-related carcinogenesis and itsapplication for prevention and early detection in clinical

虽然饮酒与吸烟一样被认为是食管癌的致癌物，但确切的机制尚不清楚。我们发现酒精代谢酶活性的差异会影响饮酒后食道DNA损伤的趋势。DNA损伤的半衰期大约是35小时。因此，长期饮酒对食道有潜在的致癌作用。饮酒后呼吸中的致癌物可能在食道酒精相关癌变中起一定的重要作用。

While alcohol drinking has been considered as carcinogen to the esophageal cancer as well as smoking, definite mechanism has been unclear.We revealed that difference in activities of alcohol metabolizing enzymes could affect the tendency of DNA damage in the esophagus after drinking. And half-life of the DNA damage was around 35 hours. Then, chronic alcohol exposure has a potential of carcinogenic effect in the esophagus. Carcinogens in the breath after drinking might in part play an important role in the alcohol-related carcinogenesis in the esophagus.