Elucidation of the immunoresponse by direct stimulation of fatty acid in Crohn disease

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To make clear that a high-fat food intake involves Crohn disease aggravation directly, I scattered fat into the ileum end during small intestinal endoscopy and compared mucosal cytokine (TNF-α) levels in between pre and post fat stimulation. The levels of TNF-α mRNA in many cases decreased after the fat stimulation, contrary to my expectation. Therefore, it was suggested that the immunoresponse in the mucosa control possibility the local inflammation in Crohn disease.