Regulation of immune response in hole body and intestinal mucosa by oral administration of staphylococcal enterotoxin B (SEB)
Regulation of immune response in hole body and intestinal mucosa by oral administration of staphylococcal enterotoxin B (SEB)
批准号:
09670542
负责人:
TSUJIKAWA Tomoyuki
金额:
$2.18万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1999
中文摘要
我们已经被简化了,预先预防了口腔SEB管理的DSS诱导性大肠杆菌,并对Vβ 8 T-cell设计的克隆缺失的影响。我们评估了Oral SEB管理对TCR α KO mice的影响。(实验1)SEB模拟DSS诱导大肠杆菌在TCR α KO米上的同步管理,并遵循延长的生存时间。Although serum Ig M of mice administered DSS increased more than that of control, the cell fractions of CD4-D1+-D1 TCRV-D1 Dim-D1 T-cells and CD4-D1+-D1 TCRV-D1 Dim-D1 T-cells did not change with or without SEB oral adminManagement。(实验2) Although TCR α KO mice have been given SEB for 9 weeks, the incidence of colitis did not decrease and the cell fractions of CD4イイD1+イエD1TCRVイイD1dimイエD1T-cells also did not change。It was suggested that CD4-D1+ D1 TCRV-D1 Dim-D1T-cell may influence the onset of the colitis on TCR?KO mice。我们倾向于预测SEB对DSS诱导大肠杆菌的TCR α KO mice的影响。因此, it is suggested that TCR_D1-イイD1+イイD1 cells which express the V_region corresponding SEB may play an important role on the onset of DSS induced colitis on TCR_KO mice。However,这是一种难以接受口腔耐受性的SEB下持续的局部炎症的条件,如TCR α KOmice的大肠杆菌。
英文摘要
We have been elucidated that oral SEB administration prevented the onset of DSS induced colitis, and influence of clonal deletion designated by Vβ8T -cells. We evaluated the effect of oral SEB administration on TCR α KO mice. (Experiment 1) Simultaneous administration of SEB ameliorated DSS induced colitis on TCR α KO mice, following prolonged survival time. Although serum Ig M of mice administered DSS increased more than that of control, the cell fractions of CD4ィイD1+ィエD1TCRVβィイD1dimィエD1T-cells and CD4ィイD1+ィエD1TCRVβィイD1dimィエD1T-cells did not change with or without SEB oral administration. (Experiment 2) Although TCR α KO mice have been given SEB for 9 weeks, the incidence of colitis did not decrease and the cell fractions of CD4ィイD1+ィエD1TCRVβィイD1dimィエD1T-cells also did not change. It was suggested that CD4ィイD1+ィエD1TCRVβィイD1dimィエD1T-cell may influence the onset of the colitis on TCR α KO mice. We elucidated that preventive effect of SEB on DSS induced colitis of TCR α KO mice. Therefore, it is suggested that TCRαィイD1-ィエD1βィイD1+ィエD1 cells which express the Vβ region corresponding SEB may play an important role on the onset of DSS induced colitis on TCR α KO mice. However, it was difficult to induce oral tolerance by SEB under condition of continuing local inflammation such as colitis of TCR α KO mice.
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Tsujikawa T,Itoh A,Bamba M et al.: "Aggressive jejunal gamma deltaT-cell lymphoma derived from intraepithelial lymphocytes: an autopsy case report"J Gastroenterol.. 33(2). 280-284 (1998)
Tsujikawa T、Itoh A、Bamba M 等人:“上皮内淋巴细胞衍生的侵袭性空肠 γ δT 细胞淋巴瘤:尸检病例报告”J Gastroenterol.. 33(2)。
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Tsujikawa T.,Satoh J.,Uda K. et al.: "Clinical importance of n-3 fatty acid-rich diet and nutritional education for the maintenance of remission in Crohn's disease"J Gastroenterol.. 35(2). 99-104 (2000)
Tsujikawa T.、Satoh J.、Uda K. 等人:“富含 n-3 脂肪酸饮食和营养教育对于维持克罗恩病缓解的临床重要性”J Gastroenterol.. 35(2)。
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Myojo S,Tsujikawa T,Sasaki M et al.: "Trophic effects of glicentin on rat small-intestinal mucosa in vivo and in vitro"J Gastroenterol.. 32(3). 300-305 (1997)
Myojo S、Tsujikawa T、Sasaki M 等:“高血糖素对体内和体外大鼠小肠粘膜的营养作用”J Gastroenterol.. 32(3)。
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Tsujikawa T, Uda K, et al.: "Changes inserum diamine oxidase activity during chemotherapy in patients with hematological malignancies"Cancer Lett.. 147(2). 195-198 (1999)
Tsujikawa T、Uda K 等人:“血液恶性肿瘤患者化疗期间血清二胺氧化酶活性的变化”Cancer Lett.. 147(2)。
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Tsujikawa T, Satoh J, Uda K, Ihara T, Okamoto T, Araki Y, Sasaki M, Fujiyama Y, Bamba T.: "Clinical importance of n-3 fatty acid-rich diet and nutritional education for the maintenance of remission in Crohn's disease"J Gastroenterol. 35(2). 99-104 (2000)
Tsujikawa T、Satoh J、Uda K、Ihara T、Okamoto T、Araki Y、Sasaki M、Fujiyama Y、Bamba T.:“富含 n-3 脂肪酸饮食和营养教育对于维持克罗恩病缓解的临床重要性
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共 16 条
The risk factor of fibrous stricture in Crohn' s disease
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批准号:23591019
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2011
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负责人:TSUJIKAWA Tomoyuki
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依托单位:
Elucidation of the immunoresponse by direct stimulation of fatty acid in Crohn disease
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批准号:20590739
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.25万
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财政年份:2008
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负责人:TSUJIKAWA Tomoyuki
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依托单位:
Regulation of AQP expression by serotonin and pathophisiology of IBS
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批准号:15590641
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:TSUJIKAWA Tomoyuki
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依托单位:
AQPexpression on intestinal epithelial cells, relation to intestinal hormone and cytekine.
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批准号:13670508
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:TSUJIKAWA Tomoyuki
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依托单位:
海外基金