Regulation of immune response in hole body and intestinal mucosa by oral administration of staphylococcal enterotoxin B (SEB)

我们已经被简化了，预先预防了口腔SEB管理的DSS诱导性大肠杆菌，并对Vβ 8 T-cell设计的克隆缺失的影响。我们评估了Oral SEB管理对TCR α KO mice的影响。（实验1）SEB模拟DSS诱导大肠杆菌在TCR α KO米上的同步管理，并遵循延长的生存时间。Although serum Ig M of mice administered DSS increased more than that of control， the cell fractions of CD4-D1+-D1 TCRV-D1 Dim-D1 T-cells and CD4-D1+-D1 TCRV-D1 Dim-D1 T-cells did not change with or without SEB oral adminManagement。（实验2） Although TCR α KO mice have been given SEB for 9 weeks， the incidence of colitis did not decrease and the cell fractions of CD4イイD1+イエD1TCRVイイD1dimイエD1T-cells also did not change。It was suggested that CD4-D1+ D1 TCRV-D1 Dim-D1T-cell may influence the onset of the colitis on TCR？KO mice。我们倾向于预测SEB对DSS诱导大肠杆菌的TCR α KO mice的影响。因此， it is suggested that TCR_D1-イイD1+イイD1 cells which express the V_region corresponding SEB may play an important role on the onset of DSS induced colitis on TCR_KO mice。However，这是一种难以接受口腔耐受性的SEB下持续的局部炎症的条件，如TCR α KOmice的大肠杆菌。

We have been elucidated that oral SEB administration prevented the onset of DSS induced colitis, and influence of clonal deletion designated by Vβ8T -cells. We evaluated the effect of oral SEB administration on TCR α KO mice. (Experiment 1) Simultaneous administration of SEB ameliorated DSS induced colitis on TCR α KO mice, following prolonged survival time. Although serum Ig M of mice administered DSS increased more than that of control, the cell fractions of CD4ィイD1+ィエD1TCRVβィイD1dimィエD1T-cells and CD4ィイD1+ィエD1TCRVβィイD1dimィエD1T-cells did not change with or without SEB oral administration. (Experiment 2) Although TCR α KO mice have been given SEB for 9 weeks, the incidence of colitis did not decrease and the cell fractions of CD4ィイD1+ィエD1TCRVβィイD1dimィエD1T-cells also did not change. It was suggested that CD4ィイD1+ィエD1TCRVβィイD1dimィエD1T-cell may influence the onset of the colitis on TCR α KO mice. We elucidated that preventive effect of SEB on DSS induced colitis of TCR α KO mice. Therefore, it is suggested that TCRαィイD1-ィエD1βィイD1+ィエD1 cells which express the Vβ region corresponding SEB may play an important role on the onset of DSS induced colitis on TCR α KO mice. However, it was difficult to induce oral tolerance by SEB under condition of continuing local inflammation such as colitis of TCR α KO mice.