The association of extracellular matrix metabolism-related gene polymorphisms with hepatic fibrosis progression and hepatocarcinogenesis in HCV chronic liver disease

HCV慢性肝病细胞外基质代谢相关基因多态性与肝纤维化进展及肝癌发生的关系

• 批准号: 20590779
• 负责人: MURAWAKI Yoshikazu
• 金额: $ 3万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590779/
• 关键词: 遺伝子多型; C型肝炎; 肝線維化; 肝発癌; 肝細胞癌; 細胞外マトリックス; TIMP-1; TIMP-2; CTGF; 細胞外アトリックス; IL-10; IL-1β; MMP-3; IL-1B; TGF-B1; MMP-1; C型慢性肝疾患; MMD-7; MMP

In chronic hepatitis C, the risk of developing hepatocellular carcinoma increases with the progression of liver fibrosis, especially higher in cirrhosis. It is necessary to degrade the surrounding fibrosis matrix of tumor for growth, invasion, and metastasis of malignant tumors, in which matrix metalloproteinases are strongly involved. Recently, functional gene polymorphisms have been identified in matrix metalloproteinases, tissue inhibitors of metalloproteinases and fibrosis-related cytokines. In this study, we analyzed these functional gene polymorphisms as the host genetic factors, and examined the association of these polymorphisms with the severity of liver fibrosis and the prognosis of hepatocellular carcinoma in chronic liver diseases C.

在慢性丙型肝炎中，发生肝细胞癌的风险随着肝纤维化的进展而增加，尤其是在肝硬变中。恶性肿瘤的生长、侵袭和转移需要降解肿瘤周围的纤维化基质，而基质金属蛋白酶在其中起着重要的作用。最近，在基质金属蛋白酶、金属蛋白酶组织抑制因子和纤维化相关细胞因子中发现了功能基因的多态性。在本研究中，我们分析了这些功能基因的多态性作为宿主遗传因素，并研究了这些基因多态性与慢性肝病患者肝纤维化的严重程度和肝细胞癌预后的关系。

项目成果

The genotypes of IL-1 betat and MMP-3 are associated with the prognosis of HCV-related hepatocellular carcinoma

IL-1 betat和MMP-3基因型与HCV相关肝细胞癌的预后相关

• 发表时间: 2010
• 期刊: Inter Med
• 作者: Okamoto K;Ishida C;Ikebuchi Y;Mandai M;Mimura K;Murawaki Y;Yuasa I.
• 通讯作者: Yuasa I.

The association of TIMP-1 and TIMP-2 gene polyorphisms with the fibrosis progression in chronic liver disease C

TIMP-1和TIMP-2基因多态性与慢性肝病纤维化进展的关系C

• 发表时间: 2011
• 作者: Harima Y;Yamasaki T;Hamabe S;Saeki I;Okita K;Terai S;Sakaida I.;Yuichiro Ikebuchi
• 通讯作者: Yuichiro Ikebuchi

The association of IL-10 and TIMP-2 gene polymorphisms with HCC carcinogenesis and the prognosis in chronic hepatitis C patients

IL-10和TIMP-2基因多态性与慢性丙型肝炎患者HCC癌变及预后的关系

• 发表时间: 2010
• 作者: Okamoto K;Ikebuchi Y;Ishida C;Murawaki Y.
• 通讯作者: Murawaki Y.

Functional gene polymorphisms of interleukin-10 are associated with liver disease progression in Japanese patients with hepatitis C virusu infection

白细胞介素10功能基因多态性与日本丙型肝炎病毒感染患者肝病进展相关

• 发表时间: 2011
• 期刊: Inter Med
• 作者: Ishida C;Ikebuchi Y;Okamoto K;Murawaki Y
• 通讯作者: Murawaki Y

Interleukin-10遺伝子多型と肝線維化進行

IL-10基因多态性与肝纤维化进展

• 发表时间: 2009
• 期刊: 薬理と治療
• 作者: 石田千尋;池淵雄一郎;岡本欣也;村脇義和
• 通讯作者: 村脇義和