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Matrix metalloproteinases in chronic liver diseases and hepatocellular carcinoma.

慢性肝病和肝细胞癌中的基质金属蛋白酶。

基本信息

批准号：
09670550
负责人：
MURAWAKI Yoshikazu
金额：
$ 2.05万
依托单位：
Tottori University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670550/
关键词：
MMP-1 MMP-2 MMP-3 MMP-9 LIVER DISEASE

项目摘要

To elucidate the clinical usefulness of serum matrix metalloproteinase (MMP)-1, MMP-2, MMP-3 and MMP-9 in chronic liver disease and hepatocellular carcinoma, we measured these enzyme concentrations in serum and liver, and compared the results with clinicopathological findings.(1)Serum MMP-1 concentration decreased during histological progression of chronic hepatitis. The serum MMP-1 test was useful clinically to differentiate active and inactive types of hepatitis in patients with chronic viral hepatitis.(2)The serum MMP-2 concentration refects mainly the amount of proMMP-2 complexed with TIMP-2. The serum MMP-2 level was markedly increased in cirrhotic patients, and may be explained by an overproduction in the cirrhotic liver. In the clinical state, the measurement of serum MMP-2 was as useful a test for diagnosing liver cirrhosis as the serum hyaluronan test.(3)The plasma MMP-9 level, as well as the MMP-2 level, was significantly increased in cirrhotic patients, probably due to overproduction in the cirrhotic liver. However, the plasma MMP-9 test was inferior to the plasma MMP-2 test for the diagnosis of cirrhosis.(4)The serum MMP-3 concentration was about 2-fold higher in the males than in the females, and 55% lower in chronic hepatitis, 53% lower in liver cirrhosis and 46% lower in hepatocellular carcinoma. The MMP-3 concentration in the cirrhotic liver was quite similar to that in the non-cirrhotic liver. The measurement of serum MMP-3 was of little use for assessing fibrolysis in chronically diseased livers.

为探讨血清基质金属蛋白酶（MMP）-1、MMP-2、MMP-3和MMP-9在慢性肝病和肝细胞癌中的临床意义，我们测定了血清和肝组织中这些酶的浓度，并与临床病理结果进行了比较。（1）血清MMP-1浓度随慢性肝炎组织学进展而降低。血清MMP-1检测对鉴别慢性病毒性肝炎患者的活动型和非活动型肝炎有一定的临床意义。（2）血清MMP-2浓度主要反映MMP-2前体与TIMP-2复合的量。肝硬化患者血清MMP-2水平明显升高，这可能是由于肝硬化患者肝脏MMP-2过度生成所致。在临床状态下，血清MMP-2的测定是诊断肝硬化的有用测试作为血清透明质酸测试。（3）肝硬化患者血浆MMP-9和MMP-2水平明显升高，可能与肝组织MMP-9和MMP-2的过度表达有关。然而，血浆MMP-9检测不如血浆MMP-2检测诊断肝硬化。（4）血清MMP-3浓度男性比女性高约2倍，慢性肝炎、肝硬化和肝癌患者血清MMP-3浓度分别比女性低55%、53%和46%。MMP-3在肝硬化和非肝硬化的浓度是非常相似的。血清MMP-3的测定对于评估慢性肝病的纤维溶解作用不大。