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Significance of HBV integration in clonal proliferation of hepatocytes

Significance of HBV integration in clonal proliferation of hepatocytes
HBV整合在肝细胞克隆增殖中的意义
批准号：
20590791
负责人：
MINAMI Masahito
金额：
$2.91万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590791/
关键词：
B型肝炎ウイルス肝発癌組み込みHBV

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中文摘要
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英文摘要
Hepatitis B virus (HBV) DNA can be integrated into the host genome and co-exist after its replication become decreased. In this study we revealed that HBV integration does not occur randomly, but is preferentially located in the certain region of the host genome. In those regions, there are many human genes related to cell proliferation, suggesting that HBV integration plays some role in modulating cell cycle. This mechanism can be related to viral persistence in the host cells and resulting liver carcinogenesis.
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会议论文
肝硬変の成因別実態と肝癌合併例の検討. 肝硬変の成因別実態2008.
按病因检查肝硬化的实际状况和肝癌并发症的病例 2008 年按病因划分的肝硬化实际状况。
DOI： --
发表时间： 2008
期刊：
影响因子： --
作者： [山口寛二, 伊藤義人, 新美敏久, 光吉博則, 安居幸一郎, 南 祐仁, 岩井眞樹, 岡上武, 吉川敏一.]
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DOI： 10.1016/j.cancergencyto.2007.09.013
发表时间： 2008-01-01
期刊： CANCER GENETICS AND CYTOGENETICS
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DOI： --
发表时间： 2010
期刊： J Gastroenterol. 45
影响因子： --
作者： [Yasui K (corresponding author), Harano Y, Mitsuyoshi H, et al. (12名中1番目)]
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A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells
DOI： 10.1016/j.canlet.2008.09.036
发表时间： 2009-03-08
期刊： CANCER LETTERS
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共 24 条
    Growth control of liver cancer cells by targeting viral-host chimeric transcript resulted from hepatitis B virus integration
    • 批准号：
      23590984
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.33万
    • 财政年份：
      2011
    • 负责人：
      MINAMI Masahito
    • 依托单位：
      Kyoto Prefectural University of Medicine
    Search for novel genomic regions related to liver carcinogenesis by using a hepatitis B virus integration site as a genetic probe
    • 批准号：
      18590742
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.43万
    • 财政年份：
      2006
    • 负责人：
      MINAMI Masahito
    • 依托单位：
      Kyoto Prefectural University of Medicine
    Treatment of chronic hepatitis B for the prevention of development of hepatocellular carcinoma and analyses of hepatitis B virus insertional mutagenesis as a first hit during multistep liver carcinogenesis.
    Treatment of hepatitis B virus without inducing antiviral resistant viruses and analyses of HBV integration at an early stage of infection before development of hepatocellular carcinoma.
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