Significance of HBV integration in clonal proliferation of hepatocytes

HBV整合在肝细胞克隆增殖中的意义

• 批准号: 20590791
• 负责人: MINAMI Masahito
• 金额: $ 2.91万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590791/
• 关键词: B型肝炎ウイルス; 肝発癌; 組み込み; HBV

Hepatitis B virus (HBV) DNA can be integrated into the host genome and co-exist after its replication become decreased. In this study we revealed that HBV integration does not occur randomly, but is preferentially located in the certain region of the host genome. In those regions, there are many human genes related to cell proliferation, suggesting that HBV integration plays some role in modulating cell cycle. This mechanism can be related to viral persistence in the host cells and resulting liver carcinogenesis.

B型肝炎病毒（HBV）DNA复制减少后，可整合到宿主基因组中并与宿主共存。在这项研究中，我们发现HBV整合不是随机发生的，而是优先位于宿主基因组的某个区域。在这些区域中，存在许多与细胞增殖相关的人类基因，表明HBV整合在调节细胞周期中起一定作用。这种机制可能与病毒在宿主细胞中的持续存在以及导致的肝癌发生有关。

项目成果

肝硬変の成因別実態と肝癌合併例の検討. 肝硬変の成因別実態2008.

按病因检查肝硬化的实际状况和肝癌并发症的病例 2008 年按病因划分的肝硬化实际状况。

• 发表时间: 2008
• 作者: 山口寛二;伊藤義人;新美敏久;光吉博則;安居幸一郎;南 祐仁;岩井眞樹;岡上武;吉川敏一.
• 通讯作者: 吉川敏一.

CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma

• DOI: 10.1016/j.cancergencyto.2007.09.013
• 发表时间: 2008-01-01
• 期刊: CANCER GENETICS AND CYTOGENETICS
• 作者: Inagaki, Yoshikazu;Yasui, Kohichiroh;Okanoue, Takeshi
• 通讯作者: Okanoue, Takeshi

Steatosis and hepatic expression of genes regulating lipid metabolism in Japanese patients infected with hepatitis C virus.

日本丙型肝炎病毒感染患者的脂肪变性和调节脂质代谢基因的肝脏表达。

• 发表时间: 2010
• 期刊: J Gastroenterol. 45
• 作者: Yasui K (corresponding author);Harano Y;Mitsuyoshi H;et al. (12名中1番目)
• 通讯作者: et al. (12名中1番目)

A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells

• DOI: 10.1016/j.canlet.2008.09.036
• 发表时间: 2009-03-08
• 期刊: CANCER LETTERS
• 影响因子: 9.7
• 作者: Gen, Yasuyuki;Yasui, Kohichiroh;Yoshikawa, Toshikazu
• 通讯作者: Yoshikawa, Toshikazu

ERK5 is a Target for Gene Amplification at 17p11 and Promotes Cell Growth in Hepatocellular Carcinoma by Regulating Mitotic Entry

• DOI: 10.1002/gcc.20624
• 发表时间: 2009-02-01
• 期刊: GENES CHROMOSOMES & CANCER
• 影响因子: 3.7
• 作者: Zen, Keika;Yasui, Kohichiroh;Yoshikawa, Toshikazu
• 通讯作者: Yoshikawa, Toshikazu