Fundamental study for development of a peptide vaccine against hepatitis C virus

丙型肝炎病毒肽疫苗开发基础研究

• 批准号: 20590799
• 负责人: YAMADA Akira
• 金额: $ 3万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590799/
• 关键词: ウイルス; 感染症; 免疫学

Fundamental studies for development of therapeutic and prophylactic vaccines against hepatitis C and liver cancers.(1) New immuno-potentiator (adjuvant) was developed and its safety and immune-potentiating activity have been demonstrated in both animal and human.(2) Hepatitis C vaccine applicable for virtually 100% of HLA types of Japanese was developed and its safety and immunological effects have been demonstrated in human clinical trials.(3) Decrease of virus RNA and normalization of liver function (ALT) were observed in clinical trials. Prophylactic effect of vaccination against carcinogenesis and recurrence of HCV-related liver cancers was also observed.

丙型肝炎和肝癌治疗性和预防性疫苗的基础研究：(1)研制出新的免疫增强剂(佐剂)，其安全性和免疫增强活性已在动物和人身上得到证实。(2)研制出可用于几乎100%日本血型的丙型肝炎疫苗，其安全性和免疫学效果已在人体临床试验中得到证实。(3)临床试验中观察到病毒RNA的减少和肝功能(ALT)的正常化。同时观察接种疫苗对丙型肝炎病毒相关性肝癌发生和复发的预防作用。

项目成果

A Phase I Study of Personalized Peptide Vaccination Using 14 Kinds of Vaccine in Combination With Low-Dose Estramustine in HLA-A24-Positive Patients With Castration-Resistant Prostate Cancer

• DOI: 10.1002/pros.21261
• 发表时间: 2011-04-01
• 期刊: PROSTATE
• 影响因子: 2.8
• 作者: Noguchi, Masanori;Uemura, Hirotsugu;Itoh, Kyogo
• 通讯作者: Itoh, Kyogo

Phase I Trial of a Personalized Peptide Vaccine for Patients Positive for Human Leukocyte Antigen-A24 With Recurrent or Progressive Glioblastoma Multiforme

• DOI: 10.1200/jco.2010.29.7499
• 发表时间: 2011-01-20
• 期刊: JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 45.3
• 作者: Terasaki, Mizuhiko;Shibui, Soichiro;Itoh, Kyogo
• 通讯作者: Itoh, Kyogo

膵臓癌におけるテーラーメイドペプチドワクチンとゲムシタビンの併用療法第II相臨床試験

定制肽疫苗与吉西他滨联合治疗胰腺癌的II期临床试验

• 发表时间: 2009
• 作者: 小松誠和;柳本泰明;山田亮;七條茂樹;伊東恭悟
• 通讯作者: 伊東恭悟

HLA-A26前立腺癌患者およびHCV感染者に対するワクチン候補ペプチドの解析

HLA-A26前列腺癌患者和HCV感染患者的疫苗候选肽分析

• 发表时间: 2008
• 作者: 牛亜梅;寺崎康展;小松誠和;野口正典;七條茂樹;山田亮;伊東恭悟
• 通讯作者: 伊東恭悟

久留米大学先端癌治療研究センター

久留米大学癌症先进治疗研究中心