Diagnosis of unstable angina pectoris by serum deoxyribonuclease I as a new diagnostic maker of myocardial ischemia

血清脱氧核糖核酸酶I诊断不稳定型心绞痛作为心肌缺血新的诊断指标

• 批准号: 20590845
• 负责人: KAWAI Yasuyuki
• 金额: $ 2.75万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590845/
• 关键词: 心臓病態学; 循環器内科; 不安定狭心症; DNase I; 酵素; 迅速診断

In this study, a high diagnostic efficacy of serum deoxyribonuclease I(DNase I) activity levels could be observed in the early phase, even in unstable angina/non ST segment elevation myocardial infarction(UAP/NSTEMI) patients who did not show elevated levels of conventional cardiac markers, such as troponin T or creatine kinase-MB. The serum DNase I can be a useful marker for the early diagnosis of UAP/NSTEMI after the onset of chest pain, irrespective of the evidence of myocardial injury.

在这项研究中，血清脱氧核糖核酸酶I（DNA酶I）活性水平的高诊断效率可以在早期观察到，即使在不稳定型心绞痛/非ST段抬高型心肌梗死（UAP/NSTEMI）患者没有显示出传统的心脏标志物，如肌钙蛋白T或肌酸激酶MB水平升高。血清DNase I可作为胸痛发作后早期诊断UAP/NSTEMI的有用指标，而不考虑心肌损伤的证据。

项目成果

Doxyribonuclease I as a useful diagnostic marker of unstable angina or non-ST-segment elevation myocardial infarction

强力核糖核酸酶 I 作为不稳定型心绞痛或非 ST 段抬高型心肌梗死的有用诊断标志物

• 发表时间: 2009
• 作者: Kawai Y;et al
• 通讯作者: et al

Deoxyribonuclease I as a useful diagnostic marker of un-stable angina or non-ST-segment elevation myocardial i-nfarction.

脱氧核糖核酸酶 I 作为不稳定型心绞痛或非 ST 段抬高型心肌梗塞的有用诊断标志物。

• 发表时间: 2009
• 作者: Kawai Y;et al.
• 通讯作者: et al.

Development of a sensitive enzyme-linked immunosorbent assay for measurement of DNase I in human serum.

• DOI: 10.1016/j.cca.2009.03.005
• 发表时间: 2009-05
• 期刊: Clinica chimica acta; international journal of clinical chemistry
• 作者: T. Nakajima;Rie Takagi;Yutaka Tajima;C. Makita;Y. Kominato;J. Kuribara;S. Ohshima;H. Tada;H. Tsurugaya;Yasuyuki Kobayashi;H. Takeshita;Yasuyuki Kawai;T. Yasuda

Serum deoxyribonuclease I activity can be a useful diagnostic marker for the early diagnosis of unstable angina pectoris or non-ST-segment elevation myocardial infarction

• DOI: 10.1016/j.jjcc.2012.01.005
• 发表时间: 2012-05-01
• 期刊: JOURNAL OF CARDIOLOGY
• 影响因子: 2.5
• 作者: Fujibayashi, Kousuke;Kawai, Yasuyuki;Yasuda, Toshihiro
• 通讯作者: Yasuda, Toshihiro