A study of the effect that deoxyribonucrease I induces apotosis in cardiac diseases

脱氧核糖核酸酶I在心脏病中诱导细胞凋亡作用的研究

• 批准号: 23591067
• 负责人: KAWAI Yasuyuki
• 金额: $ 3.41万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591067/
• 关键词: 酸化ストレス; 冠れん縮; 一過性心筋虚血; ニトロチロシン; デオキシリボ核酸分解酵素I; 冠れん縮性狭心症; DNase I; アポトーシス; 心筋症; 心筋梗塞; リモデリング; 心不全

We could not find out that deoxyribonuclease I induce apoptosis in cardiac diseases. Then, we evaluated whether nitrotyrosin (NT), a marker of oxidative stress, would elevate after vasospasm induced achtylcholine provocation test in patinets with vasospastic angina pectoris (VSAP). The serum NT levels significantly increased after coronary vasospasm induced by the test, suggensting that serum NT could be a biomarker of transient myocardial ischemia and could contribute to the development of VSAP.

我们没有发现脱氧核糖核酸酶I在心脏疾病中诱导细胞凋亡。然后，我们评估血管痉挛性心绞痛（VSAP）患者血管痉挛诱导乙酰胆碱激发试验后氧化应激标志物硝基酪氨酸（NT）是否升高。血清NT水平在冠状动脉痉挛后显著升高，提示血清NT可能是一过性心肌缺血的生物标志物，可能与VSAP的发生有关。

项目成果

Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm

• DOI: 10.1016/j.jjcc.2013.11.017
• 发表时间: 2014-08-01
• 期刊: JOURNAL OF CARDIOLOGY
• 影响因子: 2.5
• 作者: Tanabe, Kan;Kawai, Yasuyuki;Kajinami, Kouji
• 通讯作者: Kajinami, Kouji