Mechanisms in epithelial-mesenchymal transition in chronic obstructive pulmonary disease
Mechanisms in epithelial-mesenchymal transition in chronic obstructive pulmonary disease
批准号:
20590896
负责人:
ITO Isao
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
在体外培养的BEAS-2B细胞中加入适当浓度的TGF-β后,BEAS-2B细胞发生上皮-间充质转化,加入TLR配体可促进上皮-间充质转化。为了对EMT进行进一步的实验,从COPD患者中建立了诱导的多能干细胞,并且正在尝试从iPS细胞诱导II型肺细胞。
英文摘要
By adding appropriate concentration of TGF-β to cultured BEAS-2B cell, the cells exhibited epithelial-mesenchymal transition, which were enhanced by addint TLR-ligands. To perform further experiments on EMT, induced pluripotent stem cells were established from patients with COPD and inducing type II pneumocytes from iPS cells is being tried.
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DOI:
10.1378/chest.08-1783
发表时间:
2009-04-01
期刊:
CHEST
影响因子:
9.6
作者:
[Matsuoka, Hirofumi, Niimi, Akio, Mishima, Michiaki]
通讯作者:
Mishima, Michiaki
DOI:
10.1016/j.pupt.2010.05.007
发表时间:
2010-10-01
期刊:
PULMONARY PHARMACOLOGY & THERAPEUTICS
影响因子:
3.2
作者:
[Ito, Isao, Kadowaki, Seizo, Mishima, Michiaki]
通讯作者:
Mishima, Michiaki
DOI:
10.1016/j.pupt.2009.01.005
发表时间:
2009-08-01
期刊:
PULMONARY PHARMACOLOGY & THERAPEUTICS
影响因子:
3.2
作者:
[Yamaguchi, Masafumi, Niimi, Akio, Mishima, Michiaki]
通讯作者:
Mishima, Michiaki
Lipopolysaccharide induced connective tissue growth factor gene expression in human bronchial epithelial cells.
脂多糖诱导人支气管上皮细胞结缔组织生长因子基因表达。
DOI:
--
发表时间:
2010
期刊:
Respirology 15
影响因子:
--
作者:
[Nishioka M, Ogawa E, Kinose D, Haruna A, Ohara T, Ito I, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Hirai T, Muro S, Mishima M.]
通讯作者:
Mishima M.
MMP-9プロモータ遺伝子多型は上肺野優位の肺気腫病変と関連する
MMP-9启动子基因多态性与上肺野为主的肺气肿病变相关
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[伊藤功朗, 長井苑子, 半田知宏, 室繁郎, 平井豊博, 月野光博, 三嶋理晃]
通讯作者:
三嶋理晃
共 31 条
Challenge to search for lung progenitor cells and to develop alveolar type II cells from human iPS cells
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批准号:23591146
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2011
-
负责人:ITO Isao
-
依托单位:
A study for the generation mechanism and physiological relevance of left-right asymmetry of the brain
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批准号:21300125
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
-
财政年份:2009
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负责人:ITO Isao
-
依托单位:
Studies of the mechanism generating left-right asymmetry of the brain
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批准号:16300101
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.95万
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财政年份:2004
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负责人:ITO Isao
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依托单位:
INPUT-SELECTIVE SORTING OF THE NMDA RECEPTOR SUBUNITS IN MOUSE HIPPOCAMPAL PYRAMIDAL NEURONS.
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批准号:09680796
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1997
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负责人:ITO Isao
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依托单位:
Resouces of animal feces by microbial decomposition
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批准号:07680910
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.15万
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财政年份:1995
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负责人:ITO Isao
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依托单位:
Research on the development of functional and regional organization of Co-operative societies.
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批准号:59560214
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.86万
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财政年份:1984
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负责人:ITO Isao
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依托单位: